Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and CEA as the Potential Prognostic Biomarkers for Colorectal Cancer

Table 4

Univariate analysis of overall survival by the Cox proportional hazards model.

Characteristics		N	HR	95% CI	value
Age	<65 Y	87	REF	1.21–2.82	0.005
	≥65 Y	243	1.84
Sex	Male	198	REF	0.45–0.90	0.011
	Female	132	0.64
Primary site	Rectum	129	REF	0.91–1.81	0.149
	Colon	201	1.29
Tumor size	<5 cm	205	REF	0.69–1.35	0.83
	5+ cm	125	0.96
T stage	T0–T2	68	REF	0.90–2.14	0.138
	T3–T4	262	1.39
N stage	N0	185	REF	1.18–2.26	0.003
	N1–N3	145	1.63
M stage	M0	275	REF	1.52–3.30	<0.001
	M1	55	2.24
Stage	I-II	163	REF	1.19–2.30	0.003
	III-IV	167	1.65
NLR	Low	176	REF	1.41–2.73	<0.001
	High	154	1.96
PLR	Low	148	REF	1.21–2.40	0.002
	High	182	1.70
CEA (ng/mL)	Low	244	REF	1.46–2.89	<0.001
	High	86	2.05
CEA + NLR	Low	141	REF	1.67–3.42	<0.001
	High	189	2.39
CEA + PLR	Low	117	REF	1.36–2.90	<0.001
	High	213	1.99
NLR + PLR	Low	116	REF	1.44–3.09	<0.001
	High	214	2.11
CEA + NLR + PLR	Low	94	REF	1.65–3.99	<0.001
	High	236	2.57
BMI	Low	155	REF	0.26–0.52	<0.001
	High	175	0.36