Research Article
Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and CEA as the Potential Prognostic Biomarkers for Colorectal Cancer
Table 4
Univariate analysis of overall survival by the Cox proportional hazards model.
| Characteristics | N | HR | 95% CI | value |
| Age | <65 Y | 87 | REF | 1.21–2.82 | 0.005 | ≥65 Y | 243 | 1.84 |
| Sex | Male | 198 | REF | 0.45–0.90 | 0.011 | Female | 132 | 0.64 |
| Primary site | Rectum | 129 | REF | 0.91–1.81 | 0.149 | Colon | 201 | 1.29 |
| Tumor size | <5 cm | 205 | REF | 0.69–1.35 | 0.83 | 5+ cm | 125 | 0.96 |
| T stage | T0–T2 | 68 | REF | 0.90–2.14 | 0.138 | T3–T4 | 262 | 1.39 |
| N stage | N0 | 185 | REF | 1.18–2.26 | 0.003 | N1–N3 | 145 | 1.63 |
| M stage | M0 | 275 | REF | 1.52–3.30 | <0.001 | M1 | 55 | 2.24 |
| Stage | I-II | 163 | REF | 1.19–2.30 | 0.003 | III-IV | 167 | 1.65 |
| NLR | Low | 176 | REF | 1.41–2.73 | <0.001 | High | 154 | 1.96 |
| PLR | Low | 148 | REF | 1.21–2.40 | 0.002 | High | 182 | 1.70 |
| CEA (ng/mL) | Low | 244 | REF | 1.46–2.89 | <0.001 | High | 86 | 2.05 |
| CEA + NLR | Low | 141 | REF | 1.67–3.42 | <0.001 | High | 189 | 2.39 |
| CEA + PLR | Low | 117 | REF | 1.36–2.90 | <0.001 | High | 213 | 1.99 |
| NLR + PLR | Low | 116 | REF | 1.44–3.09 | <0.001 | High | 214 | 2.11 |
| CEA + NLR + PLR | Low | 94 | REF | 1.65–3.99 | <0.001 | High | 236 | 2.57 |
| BMI | Low | 155 | REF | 0.26–0.52 | <0.001 | High | 175 | 0.36 |
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