Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and CEA as the Potential Prognostic Biomarkers for Colorectal Cancer

Table 5

Multivariate analysis of overall survival by the Cox proportional hazards model.

Characteristics		N	HR	95% CI	value
Age	<65 Y	87	REF	0.99–2.38	0.053
	≥65 Y	243	1.54
Sex	Male	198	REF	0.26–0.56	<0.001
	Female	132	0.38
Primary site	Rectum	129	REF	0.90–1.88	0.158
	Colon	201	1.30
Tumor size	<5 cm	205	REF	0.62–1.34	0.639
	5+ cm	125	0.91
T stage	T0–T2	68	REF	0.44–1.23	0.248
	T3–T4	262	0.74
N stage	N0	185	REF	1.10–2.92	0.02
	N1–N3	145	1.79
M stage	M0	275	REF	1.05–2.74	0.03
	M1	55	1.70
Stage	I-II	163	REF	0.49–1.41	0.499
	III-IV	167	0.83
NLR	Low	176	REF	0.92–2.06	0.112
	High	154	1.38
PLR	Low	148	REF	0.86–1.91	0.226
	High	182	1.28
CEA (ng/mL)	Low	244	REF	0.85–1.81	0.268
	High	86	1.24
BMI	Low	155	REF	0.18–0.39	<0.001
	High	175	0.26