Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and CEA as the Potential Prognostic Biomarkers for Colorectal Cancer

Table 6

Multivariate analysis of overall survival by the clinical pathological stage.

Characteristics		Stage I-II			Stage III-IV
		HR	95% CI	value	HR	95% CI	value
Age	<65 Y	REF	0.83–3.19	0.156	REF	1.08–3.40	0.027
	≥65 Y	1.63			1.91
Sex	Male	REF	0.39–1.15	0.141	REF	0.37–1.03	0.064
	Female	0.66			0.62
Primary site	Rectum	REF	0.68–2.06	0.546	REF	0.64–1.69	0.881
	Colon	1.19			1.04
Tumor size	<5 cm	REF	0.38–1.33	0.279	REF	0.61–1.69	0.945
	5+ cm	0.71			1.02
T stage	T0–T2	REF	0.45–1.76	0.744	REF	0.31–1.77	0.499
	T3–T4	0.89			0.74
N stage	N0	REF	0.45–2.93	0.775	REF	0.73–2.38	0.354
	N1–N3	1.14			1.32
M stage	M0	REF	1.71–184.99	0.016	REF	0.99–2.81	0.052
	M1	17.79			1.68
NLR	Low	REF	1.14–3.75	0.017	REF	0.61–1.77	0.891
	High	2.06			1.04
PLR	Low	REF	0.89–3.14	0.108	REF	0.79–2.25	0.290
	High	1.67			1.33
CEA (ng/mL)	Low	REF	0.69–2.91	0.342	REF	1.13–2.85	0.013
	High	1.42			1.79