SHMT2 Drives the Progression of Colorectal Cancer by Regulating UHRF1 Expression

Figure 6

Relevance of SHMT2 induced UHRF1 expression in clinic and in vivo. (a) Real-time PCR performed in 20 CRC tissues revealed that the level of UHRF1 expression was correlated with increased SHMT2. (b) Immunohistochemical analysis of SHMT2 and UHRF1 in the same CRC tissue samples. Magnification, 100x. (c) Correlation between SHMT2 and UHRF1 expressions in CRC. (d) Immunohistochemical analysis of SHMT2, UHRF1, and Ki-67 in vivo tumors. Scale bar: 50 μm.

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