Drug-Induced Liver Injury during Consolidation Therapy in Childhood Acute Lymphoblastic Leukemia as Assessed for Causality Using the Updated RUCAM

Table 4

Variables in the equation for prediction of DILI in SR/IR patients.

	B	S.E.	Wald	Exp (B)	95% CI for EXP (B)	Sig.	Score
Age ≤5.2 years	1.338	0.376	12.663	3.813	(1.824, 7.969)	0.000	1
Treatment course ≥5	1.609	0.386	17.336	4.996	(2.343, 10.653)	0.000	2
Baseline cystatin C > 0.79 mg/L	0.726	0.345	4.429	2.066	(1.051, 4.060)	0.035	1
Baseline albumin ≤45 g/L	1.220	0.346	12.407	3.387	(1.718, 6.678)	0.000	1
Baseline GGT >17 U/L	1.750	0.421	17.305	5.756	(2.523, 13.128)	0.000	2

DILI, drug-induced liver injury; SR/IR, standard risk/intermediate risk; GGT, gamma-glutamyl transpeptidase.