Factors Prognostic of Survival in Liver Transplant Recipients with Hepatitis B Virus Related Acute-on-Chronic Liver Failure
Table 1
Demographic and clinical characters of liver transplant donors and recipients, categorised by HBV-ACLF grade.
Characteristics
HBV-ACLF 1
HBV-ACLF 2
HBV-ACLF 3
value
(n = 112)
(n = 146)
(n = 65)
Recipient
Age (years)
47.0 (22.0–70.0)
45.5 (22.0–62.0)
44.0 (23.0–62.0)
0.088
Male, n (%)
106 (94.6)
134 (91.8)
61 (93.8)
0.646
Body mass index (kg/m2)
22.7 (15.0–32.4)
23.8 (17.3–35.9)
24.2 (16.3–34.0)
0.011
Ascites, n (%)
89 (79.5)
109 (74.7)
44 (67.7)
0.218
Laboratory data
Total bilirubin (μmol/L)
431.2 (87.7–842.6)
447.9 (195.3–850.9)
405.2 (210.4–775.5)
0.167
Serum creatinine (μmol/L)
65.1 (36.6–156.0)
71.8 (23.0–725.1)
77.7 (36.0–633.1)
0.012
Serum urea (mmol/L)
5.3 (1.5–19.3)
5.5 (0.9–56.5)
5.6 (1.0–49.4)
0.977
International normalised ratio
2.0 (1.0–3.4)
3.1 (1.5–8.2)
3.5 (1.5–14.7)
0.000
Serum sodium (mmol/L)
136.9 (114.2–156.9)
137.0 (120.2–146.2)
1367.2 (121.3–153.7)
0.722
White blood cells (×109/L)
5.9 (1.4–16.2)
7.7 (2.2–27.5)
10.4 (2.6–42.6),
0.000
Neutrophils (×109/L)
4.3 (0.9–13.4)
5.6 (1.3–21.7)
8.1 (0.3–39.3),
0.000
Haemoglobin (g/L)
98.5 (59.0–148.0)
101.5 (62.0–164.0)
113.0 (52.0–157.0),
0.000
Platelets (×109/L)
65.0 (13.0–292.0)
57.5 (9.0–256.0)
78.0 (12.0–300.0)
0.036
Pretransplant scores
MELD
23.5 (13.9–34.7)
30.9 (18.1–48.0)
33.3 (20.3–48.2)
0.000
MELD-Na
24.0 (13.9–43.2)
31.5 (18.4–66.4)
34.2 (20.3–62.5)
0.000
CLIF-C ACLFs
38.2 (24.4–51.0)
45.6 (28.5–60.8)
53.1 (44.9–65.6),
0.000
COSSH-ACLFs
6.2 (4.9–8.2)
7.6 (5.6–12.0)
8.6 (6.9–16.3),
0.000
COSSH-ACLF IIs
7.0 (5.2–9.0)
8.2 (6.3–10.5)
9.0 (7.0–11.6),
0.000
Donor
Age (years)
46.0 (6.0–69.0)
44.5 (9.0–70.0)
47.0 (12.0–66.0)
0.260
Male, n (%)
89 (79.5)
127 (87.0)
55 (84.6)
0.261
Body mass index (kg/m2)
22.9 (14.8–59.0)
23.1 (12.9–33.4)
22.5 (13.8–32.3)
0.979
Fatty liver, n (%)
26 (23.2)
31 (21.2)
21 (32.3)
0.213
HBsAg positive, n (%)
10 (8.9)
20 (13.7)
5 (7.8)
0.323
Donation after cardiac death, n (%)
3 (2.7)
4 (2.7)
2 (3.1)
0.987
Cardiopulmonary resuscitation, n (%)
17 (15.2)
24 (16.4)
12 (18.5)
0.851
Laboratory data
Total bilirubin (μmol/L)
11.9 (2.2–81.9)
15.1 (3.7–59.4)
14.2 (2.4–71.4)
0.053
Serum creatinine (μmol/L)
89.9 (17.6–555.8)
85.8 (16.0–648.0)
105.5 (28.0–396.6)
0.116
International normalised ratio
1.1 (0.8–7.3)
1.1 (0.8–3.0)
1.0 (0.8–2.5)
0.867
Serum sodium (mmol/L)
145.0 (128.0–182.1)
145.8 (123.1–195.0)
144.5 (128.0–178.0)
0.499
Cold ischaemia time (hours)
7.4 (3.2–13.4)
7.8 (0.9–12.2)
8.0 (3.2–12.1)
0.245
Abbreviations: MELD, model for end-stage liver disease score; MELD-Na, MELD-sodium score; CLIF-C ACLF, chronic liver failure-consortium ACLF score; COSSH-ACLF, Chinese group on the study of severe hepatitis B-ACLF score; COSSH-ACLF II, Chinese group on the study of severe hepatitis B-ACLF II score. vs. HBV-ACLF 1; vs. HBV-ACLF 2.
