Research Article
Factors Prognostic of Survival in Liver Transplant Recipients with Hepatitis B Virus Related Acute-on-Chronic Liver Failure
Table 2
Univariate analysis of factors associated with survival after LT in recipients with HBV-ACLF.
| | Characteristics | Survived (n = 291) | Died (n = 32) | value |
| | Recipient | | Age (years) | 45.0 (22.0–70.0) | 50.5 (24.0–62.0) | 0.019 | | Male, n (%) | 271 (93.1) | 30 (93.8) | 0.625 | | Body mass index (kg/m2) | 23.4 (15.0–35.9) | 24.6 (17.3–28.7) | 0.301 | | Ascites, n (%) | 216 (74.2) | 26 (81.3) | 0.262 | | Laboratory data | | | | | Total bilirubin (μmol/L) | 434.6 (87.7–850.9) | 418.7 (233.0–747.7) | 0.717 | | Serum creatinine (μmol/L) | 68.5 (23.0–725.1) | 84.1 (34.5–529.3) | 0.054 | | Serum urea (mmol/L) | 5.4 (0.9–56.5) | 6.7 (1.2–36.9) | 0.048 | | International normalised ratio | 2.6 (1.0–14.7) | 2.9 (1.5–6.5) | 0.190 | | Serum sodium (mmol/L) | 137.0 (114.2–156.9) | 135.6 (122.9–144.3) | 0.132 | | White blood cells (×109/L) | 7.2 (1.4–37.6) | 10.0 (2.9–42.6) | 0.002 | | Neutrophils (×109/L) | 5.3 (0.9–33.5) | 7.8 (0.3–39.3) | 0.008 | | Haemoglobin (g/L) | 103.0 (52.0–164.0) | 106.5 (69.0–143.0) | 0.585 | | Platelets (×109/L) | 65.0 (9.0–292.0) | 75.0 (25.0–300.0) | 0.080 | | Grade of HBV-ACLF, n (%) | | | 0.008 | | HBV-ACLF 1 | 105 (93.8) | 7 (6.2) | | HBV-ACLF 2 | 134 (91.8) | 12 (8.2) | | HBV-ACLF 3 | 52 (80.0) | 13 (20.0) | | Pretransplant scores | | | | | MELD | 27.9 (13.9–48.2) | 31.3 (18.1–46.9) | 0.068 | | MELD-Na | 29.8 (13.9–66.4) | 34.5 (20.1–48.6) | 0.033 | | CLIF-C ACLFs | 43.6 (24.4–63.8) | 49.4 (33.7–65.6) | 0.000 | | COSSH-ACLFs | 7.1 (4.9–16.3) | 8.0 (5.4–12.2) | 0.017 | | COSSH-ACLF IIs | 7.8 (5.2–11.6) | 8.8 (6.5–11.4) | 0.001 |
| | Donor | | Age (years) | 46.0 (6.0–70.0) | 37.0 (15.0–60.0) | 0.062 | | Male, n (%) | 243 (83.5) | 28 (87.5) | 0.387 | | Body mass index (kg/m2) | 23.0 (12.9–59.0) | 22.1 (15.2–31.3) | 0.187 | | Fatty liver, n (%) | 73 (25.1) | 5 (15.6) | 0.235 | | HBsAg positive, n (%) | 27 (9.3) | 8 (25.0) | 0.013 | | Donation after cardiac death, n (%) | 7 (2.4) | 2 (6.3) | 0.210 | | Cardiopulmonary resuscitation, n (%) | 47 (16.2) | 6 (18.8) | 0.706 | | Laboratory data | | | | | Total bilirubin (μmol/L) | 14.0 (2.2–81.9) | 12.4 (4.4–25.0) | 0.274 | | Serum creatinine (μmol/L) | 89.5 (16.0–648.0) | 70.1 (31.0–376.0) | 0.402 | | International normalised ratio | 1.1 (0.8–3.0) | 1.1 (0.9–7.3) | 0.280 | | Serum sodium (mmol/L) | 145.7 (123.1–195.0) | 143.1 (128.1–173.0) | 0.476 | | Cold ischaemia time (hours) | 7.5 (0.9–13.4) | 8.5 (4.8–12.1) | 0.016 |
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