Presence of Serum Antinuclear Antibodies Does Not Impact Outcomes in HBV-Related Acute-on-Chronic Liver Failure
Table 1
Characteristics of patients with ACLF.
Variables
ANA positive (n = 17)
ANA negative (n = 99)
Z or χ2
value
Age (years)
50.0 (33.0–59.0)
51.0 (41.0–59.0)
−0.859
0.39
Male, n (%)
15 (88.2)
83 (83.8)
0.214
>0.99
HBeAg, n (%)
6 (35.3)
32 (32.3)
0.058
0.81
ALT (U/L)
322.0 (156.3–991.3)
272.3 (87.0–690.0)
−0.972
0.33
AST (U/L)
292.8 (120.3–418.7)
178.0 (91.4–419.0)
−1.296
0.20
TBil (μmol/L)
288.8 (201.8–395.8)
302.4 (212.5–377.7)
−0.121
0.90
Creatinine (μmol/L)
67.1 (55.8–80.5)
64.2 (54.4–83.9)
−0.293
0.77
Platelet (E + 09/L)
102.0 (59.5–181.0)
98.0 (70.0–134.0)
−0.894
0.37
WBC (E + 09/L)
7.1 (5.6–9.6)
6.0 (4.8–9.3)
−1.300
0.19
Neutrophils (E+09/L)
4.8 (3.6–6.5)
4.0 (2.9–6.0)
−1.261
0.21
Serum sodium (mmol/L)
139.0 (136.7–140.2)
137.6 (134.6–139.8)
−1.405
0.16
INR
1.8 (1.6–2.1)
2.1 (1.8–2.7)
−2.799
<0.01
MELD score
24.0 (21.5–26.0)
26.0 (24.0–29.0)
−2.449
0.01
MELD-Na score
25.0 (21.5–26.0)
27.0 (24.0–31.0)
−2.429
0.01
Cirrhosis, n (%)
10 (58.8%)
58 (58.1%)
0.001
0.99
SBP, n (%)
5 (29.4%)
29 (29.3%)
0.001
0.99
HE, n (%)
7 (41.2%)
44 (44.4%)
0.063
0.80
Death (%)
5 (29.4%)
37 (37.4%)
0.398
0.53
Data were expressed as median (IQR) for continuous variables and n (%) for categorical values and were compared using the Mann–Whitney U test or chi-square test. ACLF, acute-on-chronic liver failure; ANA, antinuclear antibodies; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBil, total bilirubin; ALP, alkaline phosphatase; GGT, gamma glutamyl transferase; CHE, cholinesterase; INR, international normalized ratio; HBeAg, hepatitis B e antigen; WBC, white blood cell; MELD, model for end-stage liver disease; SBP, spontaneous bacterial peritonitis; HE, hepatic encephalopathy.
