Canadian Journal of Gastroenterology and Hepatology

Research Article

The Role of von Willebrand Factor Antigen in Predicting Survival of Patients with HBV-Related Cirrhosis

Table 1

Clinical characteristics of patients at the time of enrolment.


Variable	Overall (N = 228)	vWF-Ag <1925 U/mL (N = 140)	vWF-Ag ≥1925 U/mL (N = 88)	P value

vWF-Ag (U/mL)	1738 (1448–2102)	1502 (1257–1687)	2220 (2065–2306)	<0.001
Age (year)	56 (51–59)	55 (51–58)	56 (52–59)	0.172
Female	76 (33.3%)	40 (28.6%)	36 (40.9%)	0.054
BMI (kg/m²)	21.85 (20.33–23.44)	21.95 (20.71–23.53)	21.78 (19.79–23.32)	0.156
MELD	9.90 (7.90–12.96)	9.41 (7.42–12.27)	10.84 (9.04–15.00)	<0.001
CTP stage				0.171
Stage A	47 (20.6%)	33 (23.6%)	14 (15.9%)
Stage B	129 (56.6%)	80 (57.1%)	49 (55.7%)
Stage C	52 (22.8%)	27 (19.3%)	25 (28.4%)
Laboratory test
Albumin (g/L)	34.10 (31.20–35.62)	34.10 (31.40–35.42)	34.40 (30.78–35.90)	0.872
INR	1.24 (1.10–1.35)	1.20 (1.08–1.31)	1.29 (1.13–1.44)	0.006
ALT (U/L)	24 (18–39)	24 (18–37)	25 (17–42)	0.961
AST (U/L)	42 (28–60)	40 (28–51)	47 (28–66)	0.263
TB (umol/L)	35.00 (18.00–62.00)	34.50 (17.50–53.25)	36.50 (18.00–92.75)	0.003
TCH (mmol/L)	2.84 (2.26–3.48)	2.88 (2.29–3.56)	2.79 (2.24–3.42)	0.155
UN (mmol/L)	5.70 (4.20–7.30)	5.60 (4.38–7.00)	5.70 (3.98–7.60)	0.248
Creatinine (umol/L)	65 (56–81)	67 (57–82)	63 (54–76)	0.414
LDH (U/L)	186 (152–229)	189 (154–230)	185 (149–217)	0.976
Leucocytes (10⁹/L)	3.70 (2.50–5.93)	3.85 (2.30–6.10)	3.50 (2.60–5.30)	0.959
CRP (mg/L)	8.10 (2.60–20.72)	7.55 (2.45–19.28)	11.55 (3.25–20.85)	0.942
Hemoglobin (g/L)	102 (84–118)	104 (84–118)	95 (81–115)	0.308
D-dimer (μg/L)	2282 (976–4902)	2171 (928–4564)	2888 (1153–5945)	0.056
PLT (10⁹/L)	63 (35–116)	63 (37–113)	63 (34–120)	0.663
Fibrinogen (g/L)	1.69 (1.11–2.26)	1.66 (1.12–2.46)	1.73 (1.08–2.11)	0.082
HBV DNA (log₁₀ IU/mL)	7.44 (6.05–8.01)	7.44 (5.97–8.00)	7.40 (6.41–8.17)	0.551
O blood group	84 (36.84%)	64 (45.71%)	20 (22.73%)	<0.001

vWF-Ag, von Willebrand factor antigen; BMI, body mass index; CTP, Child–Turcotte–Pugh; INR, international normalized ratio; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TB, total bilirubin; TCH, total cholesterol; UN, urea nitrogen LDH, lactic dehydrogenase; CRP, C-reactive protein; PLT, platelet count; HBV, hepatitis B virus.