The Role of von Willebrand Factor Antigen in Predicting Survival of Patients with HBV-Related Cirrhosis

Table 2

Univariate and multivariate analyses for transplant-free mortality in patients with liver cirrhosis.

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
MELD	1.13 (1.09–1.16)	<0.001	1.09 (1.05–1.13)	<0.001
CTP stage
Stage A	1 (reference)		1 (reference)
Stage B	2.42 (1.37–4.29)	0.003	1.72 (0.96–3.10)	0.069
Stage C	3.67 (1.98–6.82)	<0.001	1.95 (0.99–3.85)	0.053
Female (vs. male)	1.07 (0.74–1.54)	0.734
Age (year)	0.99 (0.96–1.02)	0.672
BMI (kg/m^2)	1.01 (0.95–1.08)	0.644
vWF-Ag (100 U/mL)	1.12 (1.08–1.17)	<0.001	1.10 (1.05–1.14)	<0.001
ALT (U/L)	1 (1.00–1.00)	0.629
AST (U/L)	1 (1.00–1.00)	0.045
TB (umol/L)	0.91 (0.78–1.06)	0.232
UN (mmol/L)	1.03 (0.99–1.08)	0.177
LDH (U/L)	1 (1.00–1.00)	0.078
Leucocytes (10^9/L)	1.02 (0.98–1.06)	0.372
CRP (mg/L)	1.01 (1.00–1.01)	0.003	1.005 (0.995–1.011)	0.121
Hemoglobin (g/L)	1 (1.00–1.01)	0.547
D-dimer (μg/L)	1 (1.00–1.00)	0.022
PLT (10^9/L)	1 (1.00–1.00)	0.073
Fibrinogen (g/L)	1.07 (0.92–1.25)	0.385
O blood group (vs. non-O)	0.56 (0.38–0.82)	0.003	0.74 (0.50–1.11)	0.145
HBV DNA (log10 IU/mL)	1.03 (0.96, 1.11)	0.353

HR, hazard ratio; vWF-Ag, von Willebrand factor antigen; BMI, body mass index; CTP, Child–Turcotte–Pugh; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TCH, total cholesterol; UN, urea nitrogen LDH, lactic dehydrogenase; CRP, C-reactive protein; PLT, platelet count; HBV, hepatitis B virus.