Research Article

Outcomes of Adult Liver Retransplantation: A Canadian National Database Analysis

Table 1

Liver retransplant recipient characteristics.

Overall2 transplants3 transplants4 transplants
N = 377N = 340 (90.2%)N = 34 (9.0%)N = 3 (0.8%)

Age at LT, years, median (IQR)52 (42–59)52 (44–59)43 (33–52)34
Male, number (%)225 (59.7)203 (59.7)19 (55.9)3 (100.0)
Time from previous transplant, days, median (IQR)5 (10–809)47 (10–642)546 (43–1998)805
 Unknown (n) = 76 (20.2%)
Creatinine at LT, μmol/L, median (IQR)104 (82–183)103 (80–186)113 (97–179)117
 Unknown (n) = 150 (39.8%)
Serum bilirubin at LT, μmol/L, median (IQR)135.5 (52.8–409.5)135.5 (53.8–414.5)117.0 (32.0–370.0)277.0
 Unknown (n) = 151 (40.1%)
INR at LT, median (IQR)1.6 (1.3–2.3)1.6 (1.3–2.4)1.6 (1.2–1.8)1.4
 Unknown (n) = 153 (40.6%)
Blood type, number (%)
 A172 (45.6)153 (45.0)17 (50.0)2 (66.7)
 AB17 (4.5)15 (4.4)1 (2.9)1 (33.3)
 B58 (15.4)56 (16.5)2 (5.9)0 (0.0)
 O129 (34.2)116 (34.1)13 (38.2)0 (0.0)
 Unknown1 (0.3)0 (0.0)1 (2.9)0 (0.0)
Liver diagnosis, number (%)
 AIH/PSC/PBC102 (27.1)91 (26.8)10 (29.4)1 (33.3)
 Alcoholic cirrhosis20 (5.3)20 (5.9)0 (0.0)0 (0.0)
 Hepatocellular carcinoma21 (5.6)18 (5.3)3 (8.8)0 (0.0)
 HBV21 (5.6)20 (5.9)1 (2.9)0 (0.0)
 HCV64 (17.0)61 (17.9)3 (8.8)0 (0.0)
 NASH10 (2.7)10 (2.9)0 (0.0)0 (0.0)
 Cryptogenic62 (16.4)51 (15.0)10 (29.4)1 (33.3)
 Other77 (20.4)69 (20.3)7 (20.6)1 (33.3)
Previous organ failure cause, number (%)
 Primary nonfunction31 (8.2)29 (8.5)2 (5.9)0 (0.0)
 Portal vein thrombosis4 (1.1)4 (1.2)0 (0.0)0 (0.0)
 Hepatic vein thrombosis18 (4.8)16 (4.7)2 (5.9)0 (0.0)
 Hepatic artery thrombosis38 (10.1)36 (10.6)1 (2.9)1 (33.3)
 Acute rejection4 (1.1)4 (1.2)0 (0.0)0 (0.0)
 Chronic rejection11 (2.9)11 (3.2)0 (0.0)0 (0.0)
 Recurrence of original disease23 (6.1)21 (6.2)2 (5.9)0 (0.0)
 Other19 (5.0)18 (5.3)1 (2.9)0 (0.0)
 Unknown/uncertain229 (60.8)201 (59.1)26 (76.5)2 (66.7)
BMI, kg/m2, median (IQR)24.9 (21.9–28.7)25.2 (22.2–29.0)23.9 (20.1–25.9)24.2
 Unknown (n) = 27 (7.2%)
MELD score at LT, median (IQR)24 (17–31)24 (17–32)23 (16–27)23
 Unknown (n) = 154 (40.8%)
Medical status, number (%)
 At home (1, 1T)74 (19.6)65 (19.1)8 (23.5)1 (33.3)
 Hospitalized (2)75 (19.9)65 (19.1)10 (29.4)0 (0.0)
 Hospitalized/ICU (3, 3F)44 (11.7)40 (11.8)3 (8.8)1 (33.3)
 ICU/ventilated (4, 4F)124 (32.9)117 (34.4)6 (17.7)1 (33.3)
 Unknown60 (16.0)53 (15.6)7 (20.6)0 (0.0)
HCV positive, number (%)54 (14.3)53 (15.6)1 (2.9)0 (0.0)
 Unknown (n) = 139 (36.9%)
CMV positive, number (%)182 (48.3)165 (48.5)17 (50.0)0 (0.0)
 Unknown (n) = 116 (30.8%)
CIT, minutes, median (IQR)443 (327–572)443 (329–572)456 (289–590)474
 Unknown (n) = 87 (23.1%)

LT, liver transplantation; IQR, interquartile range; INR, international normalized ratio; AIH, autoimmune hepatitis; PSC, primary sclerosing cholangitis; PBC, primary biliary cholangitis; HBV, hepatitis B virus; HCV, hepatitis C virus; NASH, nonalcoholic steatohepatitis; BMI, body mass index; MELD, model for end-stage liver disease; ICU, intensive care unit; CMV, cytomegalovirus; CIT, cold ischemia time.