Research Article

The Impact of Serum Parameters Associated with Kidney Function on the Short-Term Outcomes and Prognosis of Colorectal Cancer Patients Undergoing Radical Surgery

Table 4

Univariate and multivariate analyses of overall survival.

Risk factorsUnivariate analysisMultivariate analysis
HR (95% CI) valueHR (95% CI) value

Age (years)1.039 (1.028–1.050)<0.011.041 (1.029–1.053)<0.01
Sex (female/male)0.716 (0.558–0.919)0.0090.818 (0.598–1.119)0.208
BMI (kg/m2)0.969 (0.933–1.007)0.105
T2DM (yes/no)1.303 (0.925–1.836)0.130
Tumor site (colon/rectum)1.011 (0.796–1.283)0.931
Tumor stage (IV/III/II/I)2.123 (1.823–2.473)<0.012.134 (1.828–2.491)<0.01
Smoking (yes/no)1.356 (1.070–1.717)0.0121.211 (0.899–1.630)0.207
Drinking (yes/no)1.190 (0.929–1.525)0.169
Hypertension (yes/no)0.975 (0.739–1.285)0.855
CHD (yes/no)1.590 (0.928–2.722)0.091
Tumor size (≥5 cm/<5 cm)1.451 (1.147–1.837)0.0021.231 (0.972–1.560)0.085
BUN (abnormal/normal)1.348 (0.855–2.125)0.198
UA (abnormal/normal)0.712 (0.485–1.046)0.083
CysC (abnormal/normal)1.441 (1.108–1.875)0.0060.860 (0.645–1.147)0.304
Overall complications (yes/no)1.682 (1.311–2.158)<0.011.499 (1.166–1.928)0.002

-value <0.05. Abbreviations: BUN, blood urea nitrogen; UA, uric acid; CysC, cystatin C; HR, hazard ratio; CI, confidence interval; BMI, body mass index; T2DM, and type 2 diabetes mellitus.