Research Article

The Impact of Serum Parameters Associated with Kidney Function on the Short-Term Outcomes and Prognosis of Colorectal Cancer Patients Undergoing Radical Surgery

Table 5

Univariate and multivariate analyses of disease-free survival.

Risk factorsUnivariate analysisMultivariate analysis
HR (95% CI) valueHR (95% CI) value

Age (years)1.026 (1.017–1.036)<0.011.026 (1.016–1.037)<0.01
Sex (female/male)0.797 (0.639–0.994)0.0440.904 (0.682–1.199)0.484
BMI (kg/m2)0.992 (0.959–1.026)0.634
T2DM (yes/no)1.157 (0.843–1.589)0.366
Tumor site (colon/rectum)1.024 (0.827–1.268)0.829
Tumor stage (IV/III/II/I)2.053 (1.791–2.352)<0.012.053 (1.788–2.357)<0.01
Smoking (yes/no)1.288 (1.041–1.594)0.0201.189 (0.906–1.561)0.212
Drinking (yes/no)1.206 (0.965–1.507)0.100
Hypertension (yes/no)1.021 (0.800–1.303)0.868
CHD (yes/no)1.421 (0.860–2.348)0.170
Tumor size (≥5 cm/<5 cm)1.340 (1.084–1.656)0.0071.134 (0.917–1.404)0.247
BUN (abnormal/normal)1.115 (0.717–1.734)0.629
UA (abnormal/normal)0.839 (0.608–1.159)0.287
CysC (abnormal/normal)1.357 (1.068–1.723)0.0120.941 (0.725–1.223)0.651
Overall complications (yes/no)1.542 (1.227–1.937)<0.011.440 (1.144–1.814)0.002

value <0.05. Abbreviations: BUN, blood urea nitrogen; UA, uric acid; CysC, cystatin C; HR, hazard ratio; CI, confidence interval; BMI, body mass index; T2DM, and type 2 diabetes mellitus.