Canadian Journal of Gastroenterology and Hepatology / 2023 / Article / Tab 4 / Research Article
Diabetes and Metabolic Disorders: Their Impact on Cardiovascular Events in Liver Transplant Patients Table 4 Simple and multiple Cox regression analyses with cardiovascular events as the primary endpoint. Fine-gray competing risk regression analysis with cardiovascular event as the primary endpoint and CVE-unrelated mortality as the competing event.
Factors Contrast Cox regression Fine-gray competing risk regression Univariable Multivariable Multivariable HR 95% CI valuesHR 95% CI valueSHR 95% CI valuesSex F vs. M 0.23 0.08–0.63 0.004 0.34 0.12–0.94 0.038 0.25 0.09–0.69 0.008 Age at OLT 10-year increase 1.51 1.13–2.01 0.006 1.43 1.02–2.02 0.040 1.44 1.05–1.97 0.022 Etiology alcohol vs. all others 2.33 1.41–3.86 <0.001 1.31 0.70–2.46 0.400 Etiology viral hepatitis vs. all others 0.73 0.44–1.20 0.215 BMI at OLT 1 kg/m2 increase 1.08 1.01–1.15 0.019 1.05 0.97–1.12 0.236 Diabetes Pre-OLT vs. absent 4.62 2.55–8.38 <0.001 3.10 1.60–6.03 0.001 2.90 1.62–5.18 <0.001 De novo vs. absent 1.77 0.90–3.50 0.098 1.27 0.59–2.71 0.538 1.37 0.69–2.72 0.370 Hypertension Pre-OLT vs. absent 3.05 1.48–6.30 0.003 1.95 0.83–4.62 0.128 De novo vs. absent 1.97 1.04–3.76 0.039 1.14 0.55–2.37 0.723 Dyslipidemia Pre-OLT vs. absent 4.30 1.58-11.67 0.004 4.68 1.60–13.65 0.005 4.23 1.56–11.48 0.005 De novo vs. absent 2.93 1.66–5.16 <0.001 2.21 1.17–4.16 0.014 2.35 1.32–4.18 0.004 MAFLD (missing values = 100) Pre-OLT vs. absent 0.81 0.25–2.65 0.724 De novo vs. absent 0.99 0.50–1.98 0.991 Metabolic syndrome (missing values = 34) Pre-OLT vs. absent 3.24 1.36–7.68 0.008 3.13 0.90-10.87 0.072 De novo vs. absent 2.23 1.17–4.24 0.015 1.19 0.51–2.38 0.811 Therapy NonCNI vs. CNI 1.67 0.87–3.19 0.122 CNI + NonCNI vs. CNI 1.01 0.57–1.79 0.965