Diabetes and Metabolic Disorders: Their Impact on Cardiovascular Events in Liver Transplant Patients

Table 4

Simple and multiple Cox regression analyses with cardiovascular events as the primary endpoint. Fine-gray competing risk regression analysis with cardiovascular event as the primary endpoint and CVE-unrelated mortality as the competing event.

Factors	Contrast	Cox regression						Fine-gray competing risk regression
		Univariable			Multivariable			Multivariable
		HR	95% CI	values	HR	95% CI	value	SHR	95% CI	values
Sex	F vs. M	0.23	0.08–0.63	0.004	0.34	0.12–0.94	0.038	0.25	0.09–0.69	0.008
Age at OLT	10-year increase	1.51	1.13–2.01	0.006	1.43	1.02–2.02	0.040	1.44	1.05–1.97	0.022
Etiology alcohol	vs. all others	2.33	1.41–3.86	<0.001	1.31	0.70–2.46	0.400
Etiology viral hepatitis	vs. all others	0.73	0.44–1.20	0.215
BMI at OLT	1 kg/m^2 increase	1.08	1.01–1.15	0.019	1.05	0.97–1.12	0.236
Diabetes	Pre-OLT vs. absent	4.62	2.55–8.38	<0.001	3.10	1.60–6.03	0.001	2.90	1.62–5.18	<0.001
	De novo vs. absent	1.77	0.90–3.50	0.098	1.27	0.59–2.71	0.538	1.37	0.69–2.72	0.370
Hypertension	Pre-OLT vs. absent	3.05	1.48–6.30	0.003	1.95	0.83–4.62	0.128
	De novo vs. absent	1.97	1.04–3.76	0.039	1.14	0.55–2.37	0.723
Dyslipidemia	Pre-OLT vs. absent	4.30	1.58-11.67	0.004	4.68	1.60–13.65	0.005	4.23	1.56–11.48	0.005
	De novo vs. absent	2.93	1.66–5.16	<0.001	2.21	1.17–4.16	0.014	2.35	1.32–4.18	0.004
MAFLD (missing values = 100)	Pre-OLT vs. absent	0.81	0.25–2.65	0.724
	De novo vs. absent	0.99	0.50–1.98	0.991
Metabolic syndrome (missing values = 34)	Pre-OLT vs. absent	3.24	1.36–7.68	0.008	3.13	0.90-10.87	0.072
	De novo vs. absent	2.23	1.17–4.24	0.015	1.19	0.51–2.38	0.811
Therapy	NonCNI vs. CNI	1.67	0.87–3.19	0.122
	CNI + NonCNI vs. CNI	1.01	0.57–1.79	0.965