Higher Neutrophil-to-Lymphocyte Ratio (NLR) Is a Preoperative Inflammation Biomarker of Poor Prognosis in HIV-Infected Patients with Colorectal Cancer: A Retrospective Study

Table 2

Univariate and multivariate analyses of clinicopathologic variables and inflammation biomarkers in relation to OS in patients living with HIV for CRC.

Clinicopathological features	Univariate analysis		Multivariate analysis
	HR (95% CI)	values	HR (95% CI)	values
Gender
Female	Reference
Male	0.966 (0.284–3.28)	0.955
Age	0.989 (0.951–1.028)	0.572
BMI	0.976 (0.799–1.193)	0.814
Hypertension
Yes	3.344 (0.911–12.273)	0.069
DM
Yes	1.639 (0.368–7.306)	0.517
TB
Yes	3.952 (0.896–17.429)	0.07
Smoking
Yes	0.628 (0.185–2.135)	0.456
Alcohol abuse
Yes	0.561 (0.074–4.249)	0.576
Intestinal obstruction
Yes	5.678 (2.137–15.087)	<0.001	5.872 (1.369–25.18)	0.017
Hyperlipidemia
Yes	1.125 (0.409–3.095)	0.819
Duration of HIV infection (months)	0.997 (0.986–1.009)	0.616
Duration of HIV treatment (months)	0.996 (0.983–1.009)	0.537
Tumor location
Right	Reference
Left	1.026 (0.308–0.474)	0.966
Rectal	1.585 (3.413–5.3)	0.455
Histology
Squamous cell carcinoma	Reference
Adenocarcinoma	0.602 (0.201–1.809)	0.366
MMR status
dMMR	Reference
pMMR	0.841 (0.247–2.859)	0.782
AJCC stage
I-II	Reference		Reference
III-IV	5.767 (2.305–14.427)	<0.001	13.633 (3.824–48.603)	<0.001
Adjuvant treatment
No	Reference
Yes	1.225 (0.488–3.076)	0.666
CA125 (0–35 U/ml)
Increased	3.209 (1.122–9.178)	0.03	0.5 (0.079–3.183)	0.463
CA153 (0–32.3 U/ml)
Increased	1.808 (0.53–6.165)	0.344
CA199 (0–37 U/ml)
Increased	1.772 (0.708–4.434)	0.221
CEA (0–5 ng/ml)
Increased	1.23 (0.495–3.056)	0.656
CD8 count (per μl)
>912	Reference		Reference
≤912	0.342 (0.134–0.875)	0.025	0.198 (0.044–0.9)	0.036
CD4 count (per μl)
>106	Reference
≤106	2.444 (0.822–7.271)	0.108
CD4/CD8
>0.6	Reference
≤0.6	2.978 (0.693–12.801)	0.143
NLR
>2.8	Reference		Reference
≤2.8	0.337 (0.138–0.823)	0.017	0.094 (0.02–0.45)	0.003
LMR
>3.0	Reference		Reference
≤3.0	5.024 (1.977–12.772)	<0.001	0.888 (0.125–6.329)	0.905
PLR
>131.4	Reference
≤131.4	2.079 (0.874–4.948)	0.098
PNI
>45.7
≤45.7	1.953 (0.822–4.641)	0.13
SIS
0	Reference
1	1.89 (0.401–8.919)	0.421
2	2.941 (0.65–13.298)	0.161
mSIS
0	Reference		Reference
1	3.089 (0.967–9.863)	0.057	2.016 (0.457–8.891)	0.354
2	7.232 (2.056–25.436)	0.002	5.926 (0.561–62.638)	0.139

DM: diabetes mellitus; TB: tuberculosis infection status; MMR: mismatch repair; NLR: neutrophil-lymphocyte ratio; LMR: lymphocyte-monocyte ratio; PLR: platelet-lymphocyte ratio; PNI: prognostic nutritional index; SIS: systemic inflammation score; mSIS: modified systemic inflammation score; CD8: CD8+ T lymphocytes; CD4: CD4+ T lymphocytes.