Higher Neutrophil-to-Lymphocyte Ratio (NLR) Is a Preoperative Inflammation Biomarker of Poor Prognosis in HIV-Infected Patients with Colorectal Cancer: A Retrospective Study

Table 3

Univariate and multivariate analysis of clinicopathologic variables and inflammation biomarkers in relation to PFS in patients living with HIV for CRC.

Clinicopathological features	Univariate analysis		Multivariate analysis
	HR (95% CI)	values	HR (95% CI)	values
Gender
Female	Reference
Male	0.687 (0.207–2.284)	0.54
Age	0.983 (0.953–1.014)	0.285
BMI	0.99 (0.83–1.18)	0.906
Hypertension
Yes	2.339 (0.674–8.114)	0.181
DM
Yes	2.018 (0.596–6.825)	0.259
TB
Yes	4.756 (1.06–21.34)	0.042	2.035 (0.39–10.608)	0.399
Smoking
Yes	0.781 (0.27–2.259)	0.648
Alcohol abuse
Yes	0.399 (0.054–2.96)	0.369
Intestinal obstruction
Yes	3.083 (1.278–7.437)	0.012	4.453 (1.116–17.771)	0.034
Hyperlipidemia
Yes	0.71 (0.268–1.882)	0.492
Duration of HIV infection (months)	0.999 (0.99–1.008)	0.799
Duration of HIV treatment (months)	0.999 (0.989–1.008)	0.782
Tumor location
Right	Reference
Left	1.023 (0.349–0.604)	0.968
Rectal	1.742 (2.993–5.028)	0.305
Histology
Squamous cell carcinoma	Reference
Adenocarcinoma	0.479 (0.192–1.197)	0.115
MMR status
dMMR	Reference
pMMR	0.791 (0.273–2.289)	0.665
AJCC stage
I-II	Reference		Reference
III-IV	4.901 (2.196–10.937)	<0.001	8.242 (2.654–25.596)	<0.001
Adjuvant treatment
No	Reference
Yes	1.583 (0.686–3.65)	0.281
CA125 (0–35 U/ml)
Increased	2.412 (1–5.815)	0.05	0.65 (0.173–2.449)	0.524
CA153 (0–32.3 U/ml)
Increased	1.982 (0.681–5.765)	0.209
CA199 (0–37 U/ml)
Increased	1.365 (0.595–3.129)	0.462
CEA (0–5 ng/ml)
Increased	1.316 (0.599–2.894)	0.494
CD8 count (per μl)
>912	Reference
≤912	0.47 (0.201–1.098)	0.081
CD4 count (per μl)
>106	Reference
≤106	1.774 (0.613–5.136)	0.291
CD4/CD8
>0.6	Reference
≤0.6	2.067 (0.714–5.982)	0.181
NLR
>2.8	Reference		Reference
≤2.8	0.316 (0.145–0.688)	0.004	0.265 (0.088–0.8)	0.019
LMR
>3.0	Reference		Reference
≤3.0	5.546 (2.476–12.423)	<0.001	0.649 (0.065–6.47)	0.713
PLR
>131.4	Reference
≤131.4	1.38 (0.648–2.941)	0.404
PNI
>45.7			Reference
≤45.7	2.33 (1.077–5.04)	0.032	0.957 (0.11–8.31)	0.968
SIS
0	Reference		Reference
1	2.211 (0.477–10.253)	0.311	2.523 (0.394–16.165)	0.329
2	4.785 (1.095–20.912)	0.037	1.438 (0.093–22.121)	0.795
mSIS
0	Reference		Reference
1	2.381 (0.879–6.446)	0.088	1.823 (0.39–8.52)	0.446
2	7.216 (2.551–20.412)	<0.001	7.179 (0.233–220.83)	0.259

DM: diabetes mellitus; TB: tuberculosis infection status; MMR: mismatch repair; NLR: neutrophil-lymphocyte ratio; LMR: lymphocyte-monocyte ratio; PLR: platelet-lymphocyte ratio; PNI: prognostic nutritional index; SIS: systemic inflammation score; mSIS: modified systemic inflammation score; CD8: CD8+ T lymphocytes; CD4: CD4+ T lymphocytes.