Research Article
Are High Levels of Microsatellite Instability and Microsatellite Stability Identical in DNA Mismatch Repair-Deficient Colorectal Cancer Patients?
Table 2
Correlations between clinic features and MSI status in DMMR CRC patients.
| | Characteristics | MSI‐H | MSS | Total | value |
| | Total | 55 | 20 | 75 | | | Male/female | 25/30 | 13/7 | 38/37 | 0.134 | | Age (mean ± SD) (years) | 62.4 ± 14.5 | 63.8 ± 2.8 | 62.8 ± 14.0 | 0.322 | | BMI preoperative (mean ± SD) (kg/m2) | 22.5 ± 2.7 | 22.9 ± 2.5 | 22.6 ± 2.7 | 0.262 | | Smoking (yes/no) | 19/36 | 8/12 | 27/48 | 0.663 | | Drinking (yes/no) | 17/38 | 6/14 | 23/52 | 0.940 | | Family history (yes/no) | 4/51 | 1/19 | 5/70 | 0.727 | | ASA (full name) | | | | 0.202 | | 1 | 35 | 17 | 52 | | | 2 | 15 | 2 | 1 | | | 3 | 5 | 1 | 6 | | | Tumor site (colon/rectum) | 50/5 | 11/9 | 61/14 | | | TNM stage | | | | 0.103 | | I | 7 | 6 | 13 | | | II | 34 | 9 | 43 | | | III | 14 | 4 | 18 | | | IV | 0 | 1 | 1 | | | Lymphatic metastasis (yes/no) | 12/43 | 5/15 | 17/58 | 0.771 | | KRAS gene (wild/mutant) | 44/11 | 10/10 | 54/21 | 0.011∗ | | BRAF gene (wild/mutant) | 46/9 | 19/1 | 65/10 | 0.200 | | Maximum diameter of tumor (mean ± SD) (cm) | 5.4 ± 2.4 | 5.1 ± 2.4 | 5.3 ± 2.4 | 0.919 | | Recurrence (yes/no) | 5/50 | 2/18 | 7/68 | 0.905 | | CA-199 (mean ± SD) (μ/ml) | 73.7 ± 301.2 | 15.8 ± 14.6 | 59.9 ± 263.4 | 0.271 | | CA-724 (mean ± SD) (μ/ml) | 9.6 ± 11.6 | 2.8 ± 2.6 | 7.4 ± 10.1 | 0.139 | | CEA (mean ± SD) (ng/ml) | 11.6 ± 23.4 | 15.3 ± 36.4 | 12.5 ± 26.8 | 0.415 | | CD3+ (mean ± SD) (/μl) | 973.5 ± 412.6 | 1069.7 ± 353.7 | 1001.3 ± 395.5 | 0.356 | | CD4+ (mean ± SD) (/μl) | 579.4 ± 287.7 | 647.2 ± 210.5 | 598.9 ± 267.5 | 0.176 | | CD8+ (mean ± SD) (/μl) | 348.2 ± 163.4 | 366.2 ± 174.7 | 353.4 ± 165.2 | 0.97 |
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