Blood and Bronchoalveolar Lavage Fluid Metagenomic Next-Generation Sequencing in Pneumonia

Table 2

The mNGS results of bacteria and fungi for patients without paired BALF culture result (n = 10).

Patient ID	BALF mNGS result	SMRN	Blood mNGS result	SMRN	Clinical diagnosis	Changes in treatment
03	Stenotrophomonas maltophilia	14	—	—	HAP	Discontinuation of Tigecycline
	Candida albicans	6
05	Candida tropicalis	5	—	—	HAP	No change
06	—	—	Pneumocystis jirovecii	40	PJP	No change
15	—	—	—	—	CAP	Discontinuation of Amphotericin B
30	Candida tropicalis	49	—	—	HAP	No change
	Candida glabrata	4
33	Pneumocystis jirovecii	123887	Pneumocystis jirovecii	417	PJP; Bacterial infection	No change
	Acinetobacter baumannii	553
	Escherichia coli	27
36	—	—	—		CAP	No change
37	—	—	Acinetobacter baumannii	6	CAP	No change
38	—	—	—	—	HAP	No change
39	—	—	—	—	Aspiration pneumonia	No change

Abbreviations: mNGS, metagenomic next-generation sequencing; SMRN, number of reads stringently mapped to pathogen species; PJP, Pneumocystis jirovecii Pneumonia; CAP, community-acquired pneumonia; HAP, hospital-acquired pneumonia.