An Immunoinformatics Study to Predict Epitopes in the Envelope Protein of SARS-CoV-2

Table 3

List of HTL epitopes that are antigenic and nonallergic and bind with an affinity IC50 value of less than 200 nm with MHC-II alleles.

Epitope	Position in sequence	Interaction of MHC-II alleles having IC50 value <200 nm	Antigenic	Allergen	Toxic	IFN-γ epitope prediction	Population coverage (%)	Binding score (kcal/mol) of epitopes with MHC-II
VLLFLAFVV	17	HLA-DRB115:01; HLA-DRB112:01; HLA-DRB104:05; HLA-DRB104:04; HLA-DRB101:01; HLA-DRB501:01; HLA-DRB107:01	Yes	No	No	Positive	53	−90.4
FLAFVVFLL	20	HLA-DRB104:05; HLA-DRB104:04; HLA-DRB115:01; HLA-DRB104:01; HLA-DRB101:01; HLA-DRB107:01; HLA-DRB104:04; HLA-DRB109:01; HLA-DRB501:01	Yes	No	No	Positive	62	−80.05
LLVTLAILT	27	HLA-DRB101:01; HLA-DRB115:01; HLA-DRB107:01; HLA-DRB104:04; HLA-DRB107:01; HLA-DRB104:05; HLA-DRB107:01; HLA-DRB115:01; HLA-DRB111:01	Yes	No	No	Positive	57	−51.01
LAILTALRL	31	HLA-DRB101:01; HLA-DRB115:01; HLA-DRB107:01; HLA-DRB104:04; HLA-DRB104:05; HLA-DRB111:01	Yes	No	No	Positive	57	−64.52
YVYSRVKNL	57	HLA-DRB104:01; HLA-DRB104:05; HLA-DRB107:01; HLA-DRB111:01; HLA-DRB501:01; HLA-DRB101:01	Yes	No	No	Positive	48	−55.9