Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

Table 2

Association analysis of IFN pathway gene polymorphisms in children with HBV infection.

Gene	SNP	Genotype	Case (%)	Controls (%)	Crude OR (95% CI)	value	Adjust OR (95% CI)	value
IFNGR1	rs3799488	TT	131 (48.0)	177 (52.1)	1		1
		CT	119 (43.6)	136 (40)	1.182 (0.847–1.651)	0.326	1.213 (0.865–1.701)	0.262
		CC	23 (8.4)	27 (7.9)	1.151 (0.631–2.098)	0.646	1.137 (0.620–2.084)	0.679
	rs2234711	GG	113 (41.9)	113 (33.1)	1		1
		AG	116 (43.0)	180 (52.8)	0.644 (0.454–0.914)	0.014	0.641 (0.450–0.913)	0.014
		AA	41 (15.2)	48 (14.1)	0.854 (0.522–1.397)	0.53	0.851 (0.518–1.399)	0.525
IFNGR2	rs1059293	TT	205 (74.8)	264 (77.9)	1		1
		CT	65 (23.7)	68 (20.1)	1.231 (0.837–1.811)	0.291	1.209 (0.819–1.785)	0.339
		CC	4 (1.5)	7 (2.0)	0.736 (0.213–2.548)	0.628	0.825 (0.235–2.893)	0.764
IL12B	rs3212227	TT	77 (28.3)	90 (26.5)	1		1
		GT	138 (50.7)	179 (52,6)	0.901 (0.618–1.313)	0.588	0.911 (0.623–1.332)	0.629
		GG	57 (21.0)	71 (20.9)	0.938 (0.591–1.490)	0.788	0.917 (0.575–1.463)	0.717
IFNG	rs1861494	TT	129 (47.1)	156 (45.1)	1		1
		TC	108 (39.4)	158 (45.7)	0.827 (0.589–1.159)	0.27	0.818 (0.581–1.151)	0.249
		CC	37 (13.5)	32 (9.2)	1.398 (0.825–2.370)	0.213	1.399 (0.821–2.386)	0.217

Adjusting for sex and age.