Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

Table 3

Associated between SNPs and HBV infection in children using genetic models.

Gene	SNP	Model	Genotype	Crude OR (95% CI)	value	Adjusted OR (95% CI)	value
IFNGR1	rs3799488	Dominant	TC + CC/TT	1.177 (0.856–1.619)	0.316	1.200 (0.870–1.657)	0.267
		Recessive	TT + TC/CC	1.067 (0.597–1.906)	0.828	1.041 (0.579–1.872)	0.893
		Codominant	TT/CT	1.182 (0.847–1.651)	0.326	1.212 (0.864–1.698)	0.265
			TT/CC	1.151 (0.631–2.098)	0.646	1.132 (0.613–2.090)	0.692
		Overdominant	TT + CC/TC	1.159 (0.839–1.601)	0.370	1.192 (0.859–1.653)	0.293
	rs2234711	Dominant	GA + AA/GG	0.689 (0.495–0.958)	0.027	0.685 (0.491–0.957)	0.027
		Recessive	GG + GA/AA	1.093 (0.696–1.716)	0.700	1.092 (0.693–1.723)	0.704
		Codominant	GG/AG	0.644 (0.454–0.914)	0.014	0.643 (0.452–0.914)	0.014
			GG/AA	0.854 (0.522–1.397)	0.530	0.850 (0.516–1.400)	0.523
		Overdominant	GG + AA/GA	0.674 (0.489–0.929)	0.016	0.671 (0.485–0.928)	0.016
IL12B	rs32172227	Dominant	TG + GG/TT	0.912 (0.638–1.303)	0.612	0.913 (0.636–1.309)	0.619
		Recessive	TT + TG/GG	1.004 (0.679–1.486)	0.982	0.975 (0.656–1.449)	0.901
		Codominant	TT/GT	0.901 (0.618–1.313)	0.588	0.911 (0.623–1.333)	0.631
			TT/GG	0.938 (0.591–1.490)	0.788	0.916 (0.574–1.463)	0.713
		Overdominant	TT + GG/TG	0.926 (0.673–1.274)	0.638	0.945 (0.685–1.305)	0.732
IFNGR2	rs1059293	Dominant	TC + CC/TT	1.185 (0.815–1.723)	0.375	1.176 (0.806–1.716)	0.401
		Recessive	TT + TC/CC	0.703 (0.204–2.425)	0.577	0.792 (0.227–2.768)	0.715
		Codominant	TT/CT	1.231 (0.837–1.811)	0.291	1.209 (0.819–1.785)	0.338
			TT/CC	0.736 (0.213–2.548)	0.628	0.816 (0.233–2.855)	0.750
		Overdominant	TT + CC/TC	1.239 (0.843–1.821)	0.274	1.214 (0.823–1.791)	0.327
IFNG	rs1861494	Dominant	TC + CC/TT	0.923 (0.672–1.268)	0.621	0.915 (0.663–1.262)	0.589
		Recessive	TT + TC/CC	1.532 (0.927–2.532)	0.096	1.541 (0.927–2.562)	0.095
		Codominant	TT/TC	0.827 (0.589–1.159)	0.270	0.816 (0.579–1.150)	0.246
			TT/CC	1.398 (0.825–2.370)	0.213	1.397 (0.821–2.377)	0.217
		Overdominant	TT + CC/TC	0.774 (0.561–1.068)	0.119	0.766 (0.553–1.060)	0.108

Adjusting for sex and age.