Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

Table 4

Association between SNPs and risk of HBV breakthrough infection in children born to HBsAg (+) mothers.

Gene	SNP	Genotype	Case	Controls	Crude OR (95% CI)	value	Adjust OR (95% CI)	value
IFNGR1	rs3799488	TT	19 (47.5)	67 (55.4)	1		1
		CT	16 (40.0)	49 (40.5)	1.151 (0.538–2.463)	0.716	1.112 (0.514–2.403)	0.787
		CC	5 (12.5)	5 (4.1)	3.526 (0.923–13.47)	0.065	3.492 (0.892–13.669)	0.073
	rs2234711	GG	18 (45.0)	38 (31.1)	1		1
		AG	15 (37.5)	70 (57.4)	0.452 (0.205–0.998)	0.049	0.464 (0.208–1.033)	0.060
		AA	7 (17.5)	14 (11.5)	1.056 (0.363–3.067)	0.921	1.034 (0.351–3.050)	0.951
IFNGR2	rs1059293	TT	30 (75.0)	90 (75.0)	1		1
		CT	8 (20.0)	28 (23.3)	0.857 (0.353–2.083)	0.734	0.915 (0.372–2.251)	0.846
		CC	2 (5.0)	2 (1.7)	3.00 (0.405–22.235)	0.282	3.332 (0.432–25.723)	0.248
IL12B	rs3212227	TT	12 (30.0)	30 (24.6)	1
		GT	18 (45.0)	69 (56.6)	0.652 (0.280–1.521)	0.323	0.673 (0.285–1.585)	0.365
		GG	10 (25.0)	23 (18.9)	1.087 (0.400–2.954)	0.870	1.178 (0.426–3.257)	0.752
IFNG	rs1861494	TT	20 (50.0)	56 (43.8)	1		1
		TC	14 (35.0)	61 (47.7)	0.643 (0.297–1.393)	0.262	0.680 (0.310–1.489)	0.335
		CC	6 (15.0)	11 (8.6)	1.527 (0.499–4.672)	0.458	1.466 (0.471–4.564)	0.509

Adjusting for sex and age.