Cytotoxin-Associated Gene A-Positive Helicobacter pylori Promotes Autophagy in Colon Cancer Cells by Inhibiting miR-125b-5p

Figure 3

CagA overexpression promotes, while miR-125b-5p inhibits, the proliferation and invasion of colon cancer cells. (a) and (d) represent that on the fifth day, transfection of CagA plasmid significantly increased, while transfection of miR-125b-5p significantly decreased the viability of both DLD-1 (a) and SW620 (d) cells. (b) and (e) represent the transfection of CagA plasmid significantly increased, while transfection of miR-125b-5p significantly decreased the proliferation of both DLD-1 (b) and SW620 (e) cells. (c) and (f) represent the transfection of CagA plasmid significantly increased, while transfection f miR-125b-5p significantly decreased the invasion of DLD-1 (c) and SW620 (f) cells. , compared with mimic-NC + OE-NC, and , compared with mimic-NC + OE-CagA group.

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