Faecalibacterium prausnitzii: A Next-Generation Probiotic in Gut Disease Improvement

Figure 1

Mechanism underlying the anti-inflammation and enhancement of barrier function of Faecalibacterium prausnitzii. The effector molecules of F. prausnitzii encourage secretion of IL-10 from peripheral blood mononuclear cells (PBMCs), dendritic cells (DCs), and macrophages, and thus, proinflammatory cytokines are downregulated. The metabolites from F. prausnitzii, butyrate and salicylic acid, can block the secretion of IL-8 through inhibition of activation NF- κβ signaling and inflammation. The metabolites and effector molecules of F. prausnitzii can enhance the barrier function through providing growth factors from mucin degradation. F. prausnitzii could interact with the host by strengthening the intestinal barrier or modulating mucin turnover and immune responses.