Predictive Immunological, Virological, and Routine Laboratory Markers for Critical COVID-19 on Admission

Table 4

IL-6, IL-10, sIL-2rα (sCD25),IL1β, IL-1Ra, and IL-18 cutoff values and ORs (95% CI) for the risk of developing critical COVID-19 in the age-adjusted univariate and multivariate analyses.

Variable	Cutoff (pg/mL)	OR (95% CI) univariate model	OR (95% CI) multivariate model
IL-6	142.5	8.76 (3.56–21.54)	—
IL-10	10.8	20.73 (5.83–73.71)	8.09 (1.73–37.97)
sIL-2rα (sCD25)	804.5	12.46 (4.00–38.8)	11.07 (2.39–51.32)
IL1β	4.68	4.57 (1.81–11.53)	—
IL-1Ra	88.4	4.14 (1.82–9.41)	—
IL-18	144.0	16.10 (5.83–44.46)	10.68 (2.87–39.69)

Abbreviations: CI, confidence interval; COVID-19, coronavirus disease 2019; IL-1Ra, IL-1 receptor antagonist; OR, odds ratio; sIL-2rα, serum IL-2 receptor alpha (sCD25).