Molecular Assessment of Domain I of Apical Membrane Antigen I Gene in Plasmodium falciparum: Implications in Plasmodium Invasion, Taxonomy, Vaccine Development, and Drug Discovery

Table 2

Similar conserved amino acid sequences in Domain I of AMA1 in Plasmodium species that infect human.

Amino acid positions	Pf	Pv	Pm	Po	Pk
7–13	FLKPVAT	FLKPVAT	FLTPVAT	FLKPVAT	FLTPVAT
18–26	LKDGGFAFP	LKDGGFAFP	LKSGGFAFP	LKSGGFAFP	LKEGGFAFP
33–36	SPMT	SPMT	SPVT	SPIS	SPIT
44–47	YKDN	YKDN	YEEH	YNEN	YKEN
53–59	LDELTLC	LNDIALC	LNDLSLC	LNDMSLC	LNDIALC
79–83	PAVYD	PAVYD	PAVYD	PAVYD	PAVYD
101–105	GPRYC	GPRYC	GPRYC	GPRYC	GPRYC
131–136	YLSKNV	YLSKNV	YLSKNV	YLSKNL	YLSKNV
144–149	CPRKNL	CPRKNL	CPRKSL	CPRNNL	CPRKNL

Pf = Plasmodium falciparum; Pv = Plasmodium vivax; Pm = Plasmodium malariae; Po = Plasmodium ovale; Pk = Plasmodium knowlesi.