The Investigation of HBV Pre-S/S Gene Mutations in Occult HBV Infected Blood Donors with anti-HBs Positive

Table 3

The mutations in the pre-S/S region of OBI_B and OBI_C strains with anti-HBs positive or negative.

Protein	Lenth	Mutation	Genotype B	Genotype C	Sites common B/C
		Sites	Number of mutation	Number of mutation	Number of mutation
			Sites/frequency (mutation rate)	Sites/frequency (mutation rate)	Sites/frequency (mutation rate)
pre-S1	119	anti-HBs+/anti-HBs-	0/0	3/11 (1.32%)	2/4 (0.31%)
		anti-HBs+	3/3 (0.84%)	17/22 (3.70%)
		anti-HBs-	2/2 (1.68%)	6/6 (2.52%)
pre-S2	55	anti-HBs+/anti-HBs-	1/2 (0.91%)	2/6 (1.56%)	0/0
		anti-HBs+	6/6 (3.64%)	11/13 (4.73%)
		anti-HBs-	1/1 (1.82%)	3/3 (2.73%)
S	144	anti-HBs+/anti-HBs-	8/20 (1.39%)	10/37 (2.34%)	20/75 (2.48%)
		anti-HBs+	13/14 (2.43%)	20/30 (3.47%)
		anti-HBs-	27/38 (4.40%)	31/49 (6.81%)
pre-S/S	318	anti-HBs+/anti-HBs-	9/22 (1.03%)	15/54 (1.93%)	22/79 (1.60%)
		anti-HBs+	22/23 (2.09%)	48/65 (3.75%)
		anti-HBs-	30/41 (3.95%)	40/58 (5.43%)

OBI, occult hepatitis B virus infection; anti-HBs, hepatitis B surface antibody.