Research Article
The Investigation of HBV Pre-S/S Gene Mutations in Occult HBV Infected Blood Donors with anti-HBs Positive
Table 4
High-frequency mutations of envelope protein in OBI strains classified with genotypes and the presence and absence of anti-HBs.
| | Region | Mutation | Frequency in anti-HBs (+) strains | Frequency in | P | | anti-HBs (−) strains |
| | OBIC | | | | | | pre-S1 | A60V | 2/8 (25%) | 1/3 (33.3%) | 1 | | | G73S | 4/8 (50%) | 1/3 (33.3%) | 1 | | | V90A | 2/8 (25%) | 1/3 (33.3%) | 1 | | pre-S2 | I42T | 3/8 (37.5%) | 1/3 (33.3%) | 1 | | S | T118R/V/M | 3/10 (30%) | 1/11 (9.1%) | 0.311 | | | I126T/M | 3/10 (30%) | 2/11 (18.2%) | 0.635 | | | D144E/N/A | 1/10 (10%) | 3/11 (27.3%) | 0.586 | | OBIB | | | | | | S | N40S | 0/10 (0%) | 3/11 (27.3%) | 0.214 | | OBIB/OBIC | | | | | | S | V/T47K/A/E | 3/10 (30%) | 4/11 (36.4%) | 1 | | | K122R | 0/10 (0%) | 5/11 (45.5%) | 0.035 | | | M133T/L | 1/10 (10%) | 3/11 (27.3%) | 0.586 | | | F134I/L/R | 1/10 (10%) | 3/11 (27.3%) | 0.586 | | | K160R/S/K | 1/10 (10%) | 5/11 (45.5%) | 0.149 | | | V168A | 1/10 (10%) | 3/11 (27.3%) | 0.586 | | | S174N | 3/10 (30%) | 3/11 (27.3%) | 1 | | | L175S | 2/10 (20%) | 3/11 (27.3%) | 1 | | | V177A | 3/10 (30%) | 2/11 (18.2%) | 0.635 |
|
|
Anti-HBs, hepatitis B surface antibody; OBIB, OBI genotype B; OBIC, OBI genotype C.
|
