Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains

Table 1

Cytotoxicity test after Bdq treatments (OD₄₅₀, ).

	4 h	8 h	24 h	48 h	F test	value
Blank well	0.19 ± 0.00	0.20 ± 0.00	0.21 ± 0.00	0.25 ± 0.00	302.383	0.001
Control well	2.61 ± 0.07	2.75 ± 0.01	3.28 ± 0.00	3.63 ± 0.01	582.410	0.001
Experiment well (MIC)	3.00 ± 0.00	3.94 ± 0.04	4.02 ± 0.05	4.21 ± 0.01	770.868	0.001
Experiment well (10 MIC)	2.98 ± 0.01	3.17 ± 0.02	3.70 ± 0.01	4.17 ± 0.02	3496.973	0.001
Experiment well (20 MIC)	2.64 ± 0.01	2.93 ± 0.02	3.67 ± 0.02	3.98 ± 0.04	1965.094	0.001
F test	4501.332	11129.366	11417.576	21747.170	—	—
value	0.001	0.001	0.001	0.001	—	—
Survival rate (MIC)	100.00	100.00	100.00	100.00	—	—
Survival rate (10 MIC)	100.00	100.00	100.00	100.00	—	—
Survival rate (20 MIC)	100.00	100.00	100.00	100.00	—	—
Inhibition rate (MIC)	0	0	0	0	—	—
Inhibition rate (10 MIC)	0	0	0	0	—	—
Inhibition rate (20 MIC)	0	0	0	0	—	—

Survival rate = [(experiment well-blank well)/(control well-blank well)] × 100%. Inhibition rate = [(control well-experiment well)/(control well-blank well)] × 100%.