Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains

Table 2

Intracellular CFUs detected in macrophages infected with H37Rv and MDR-MTB strains after Bdq treatment .

	4 h before administration	4 h after administration	8 h after administration	24 h after administration	48 h after administration	F test	value
H37Rv strains
Control	120.00 ± 4.00	104.67 ± 9.87	114.00 ± 5.29	102.67 ± 13.61	85.33 ± 6.43	7.111	0.006
MIC	120.00 ± 4.00	40.00 ± 4.00	36.00 ± 4.00	33.33 ± 6.11	26.67 ± 11.55	103.085	0.001
10 MIC	120.00 ± 4.00	33.33 ± 6.11	22.67 ± 4.62	17.33 ± 2.31	14.67 ± 4.16	303.890	0.001
20 MIC	120.00 ± 4.00	26.67 ± 6.11	24.00 ± 6.93	21.33 ± 2.31	10.67 ± 1.16	279.210	0.001
F-test	—	83.090	201.612	81.943	74.621	—	—
value	—	0.001	0.001	0.001	0.001	—	—
MDR-MTB strains
Control	114.67 ± 7.57	92.67 ± 6.43	102.67 ± 4.62	96.67 ± 11.55	83.33 ± 5.77	7.128	0.006
MIC	114.67 ± 7.57	80.67 ± 7.02	74.67 ± 7.57	67.33 ± 11.02	41.33 ± 2.31	36.062	0.001
10 MIC	114.67 ± 7.57	74.67 ± 7.57	53.33 ± 3.06	34.67 ± 4.62	30.00 ± 7.21	90.818	0.001
20 MIC	114.67 ± 7.57	42.00 ± 13.12	28.00 ± 6.93	22.00 ± 2.00	19.33 ± 1.16	84.097	0.001
F test	—	17.604	88.732	48.437	102.507	—	—
value	—	0.001	0.001	0.001	0.001	—	—

Control: No drug on macrophages infected by MTB. : The value of 4 h before administration and other group was less than 0.05. : The value of 4 h after administration and other group was less than 0.05. : The value of 8 h after administration and other group was less than 0.05. : The value of 24 h after administration and other group was less than 0.05. ^a: The value of control and other group was less than 0.05. ^b: The value of MIC and other group was less than 0.05. ^c: The value of 10MIC and other group was less than 0.05.