Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains

Table 3

Levels of IL-12/23 p40 in culture supernatants of macrophages infected with H37Rv and MDR-MTB strains after Bdq administration (pg/ml, ).

	4 h before administration	4 h after administration	24 h after administration	48 h after administration	F test	value
H37Rv strains
Control	737.87 ± 93.61	722.80 ± 2.70	875.86 ± 21.11	867.81 ± 1.63	5.834	0.061
Bdq	737.87 ± 93.61	749.83 ± 55.78	795.97 ± 16.55	797.54 ± 5.12	0.629	0.633
t-test	—	−0.684	4.211	18.491	—	—
value	—	0.564	0.052	0.003	—	—
MDR-MTB strains
Control	757.70 ± 52.47	722.54 ± 2.64	760.78 ± 0.61	752.17 ± 1.80	0.890	0.519
Bdq	757.70 ± 52.47	852.42 ± 1.85	699.80 ± 61.95	767.13 ± 70.27	2.746	0.177
t-test	—	−56.980	1.392	−0.301	—	—
value	—	0.001	0.299	0.792	—	—