Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains

Table 4

Levels of TNF-α in culture supernatants of macrophages infected with H37Rv and MDR-MTB strains after Bdq administration (pg/ml, ).

	4 h before administration	4 h after administration	24 h after administration	48 h after administration	F test	value
H37Rv strains
Control	307.95 ± 17.27	385.20 ± 1.52	500.39 ± 0.37	436.28 ± 0.57	175.914	0.001
Bdq	307.95 ± 17.27	382.50 ± 9.66	407.93 ± 53.18	444.71 ± 8.41^#	8.129	0.035
t-test	—	0.390	2.459	−1.415	—	—
value	—	0.734	0.133	0.293	—	—
MDR-MTB strains
Control	334.96 ± 9.33	402.47 ± 2.85	451.83 ± 1.19	475.95 ± 0.54	320.338	0.001
Bdq	334.96 ± 9.33	392.36 ± 45.41	514.09 ± 10.16	447.54 ± 11.60	19.648	0.007
t-test	—	0.314	−8.606	3.461	—	—
value	—	0.783	0.013	0.074	—	—