Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains

Table 5

Levels of IL-6 in culture supernatants of macrophages infected with H37Rv and MDR-MTB strains after Bdq administration (pg/ml, ).

	4 h before administration	4 h after administration	24 h after administration	48 h after administration	F test	value
H37Rv strains
Control	9.75 ± 2.91	11.05 ± 1.07	59.96 ± 0.35	87.06 ± 0.37	1171.658	0.001
Bdq	9.75 ± 2.91	11.81 ± 0.00	46.36 ± 0.00	61.95 ± 3.17	288.665	0.001
t-test	—	−1.000	54.400	11.135	—	—
value	—	0.423	0.001	0.008	—	—
MDR-MTB strains
Control	7.69 ± 0.00	13.45 ± 0.64	77.87 ± 0.21	119.50 ± 0.84	19757.538	0.001
Bdq	7.69 ± 0.00	11.81 ± 0.00	105.09 ± 0.00	107.40 ± 9.75	261.443	0.001
t-test	—	3.593	−181.467	1.748	—	—
value	—	0.069	0.001	0.223	—	—