Compilation of 10 Years of MIRU-VNTR Data: Canadian National Tuberculosis Laboratory’s Experience
Table 1
Major Canadian MIRU-VNTR patterns and their closest MLVA, SpolDB4 ST, and phylogenetic tree matches against MTBC lineages contained in the MIRU-VNTRplus database.
ID
MLVA MtbC15-19
Top MLVA MtbC15-19 matches
Distance match
SpolDB4 ST match
Closest lineage match (ST)
Closest match from a phylogenetic tree
Cluster 412
115-44
115-44 113-44
0 0.41
19 19
EAI EAI
EAI
Cluster 442
113-44
113-44 115-44
0 0.41
19 19
EAI EAI
EAI
Cluster 2814
4063-15
143-62 82-15 83-15
0.21 0.25 0.25
(−) 50 287
X Haarlem Haarlem
TUR, X, Haarlem
Cluster 2425
NM-62
127-56 74-26 153-64
0.25 0.29 0.29
20 (−) 451
LAM Cameroon H37Rv
H37Rv, Cameroon
Cluster 1729
NM-15
140-15 133-15 139-60
0.13 0.17 0.17
34 34 71
S S S
S
Cluster 2327
21260-15
72-26 73-26 75-26
0.29 0.29 0.29
61 61 (−)
Cameroon Cameroon Cameroon
H37Rv, Cameroon
Cluster 1266
NM-1039
150-32 69-25 148-32
0.36 0.41 0.41
26 53 357
Delhi/CAS Ghana Delhi/CAS
Delhi/CAS
Cluster 2712
NM-15
92-15 142-15
0.17 0.21
47 119
Haarlem X
Haarlem
Cluster 2726
NM-15
84-28 92-15
0.167 0.167
1586 47
Haarlem Haarlem
Haarlem
Cluster 1952
NM-69
140-15 133-15 21-13
0.29 0.33 0.37
34 71 (−)
S S UgandaII
S
NM, no match; MTBC lineages contained in the MIRU-VNTRplus database include EAI, TUR, X, Haarlem, H37Rv, Cameroon, S, Delhi/CAS; ST, SpolDB4 strain type with missing STs in MIRU-VNTRplus represented by a hyphen sign (−) in this table. Dendrogram is shown in supplementary material S7.
