Canadian Journal of Infectious Diseases and Medical Microbiology

Research Article

Analysis of the Influencing Factors of Immunological Nonresponders in Wuhan, China

Table 2

The comparison of follow-up and baseline conditions of the study patients.


Variable	Baseline	Follow-up

Years since HIV diagnosis	0.1 (0.1, 0.2)	3.3 (2.0, 5.7)	0.000
Years since HAART	—	3.0 (1.8, 5.0)	—
Follow-up times	—	15.0 (11.0, 22.0)	—
HAART options			0.000
3TC + TDF + EFV	153 (69.5%)	118 (53.6%)
3TC + AZT + EFV	30 (13.6%)	27 (12.3%)
NVP+3TC + AZT	24 (10.9%)	9 (4.1%)
Others	13 (5.9%)	66 (30.0%)
Co-trimoxazole			0.000
Yes	156 (70.9%)	195 (88.6%)
No	64 (29.1%)	23 (10.5%)
Missing	0 (0.0%)	2 (0.9%)
Liver function impairment			0.000
Yes	98 (44.1%)	74 (33.3%)
No	124 (55.9%)	125 (56.3%)
Missing	0 (0.0%)	23 (10.4%)
Leukopenia			0.000
Yes	91 (41.4%)	46 (20.9%)
No	129 (58.6%)	150 (68.2%)
Missing	0 (0.0%)	24 (10.9%)
Anemia			0.000
Yes	78 (35.5%)	24 (10.9%)
No	144 (64.5%)	174 (78.2%)
Missing	0 (0.0%)	24 (10.9%)
Viral load (copies/ml)	97830.0 (35476.0, 254172.0)	0.0 (0.0, 20.0)	0.000
CD4 counts (cells/μl)	39.0 (20.3, 105.8)	162.0 (128.3, 183.0)	0.000
WBC count (×10⁹/L)	4.2 (3.3, 5.1)	4.8 (4.0, 5.7)	0.000
Plt count (×10⁹/L)	174.0 (135.8, 218.3)	205.5 (170.3, 241.5)	0.000
Hb count (g/L)	128.0 (113.0, 140.0)	144.0 (130.0, 153.0)	0.000
Cr (μmol/L)	71.8 (61.0, 82.5)	70.0 (60.9, 82.0)	0.393
TG (mmol/L)	1.4 (0.9, 1.9)	1.5 (1.0, 2.4)	0.027
TC (mmol/L)	3.8 (3.3, 4.3)	4.4(3.8, 5.0)	0.000
FPG (mmol/L)	5.5(4.9, 6.4)	5.5 (5.2, 6.3)	0.159
AST (U/L)	28.0 (21.0, 37.0)	25.0 (20.0, 31.0)	0.000
ALT (U/L)	23.5 (14.0, 41.0)	20.0 (14.0, 28.5)	0.002
T.BIL (μmol/L)	10.0 (7.5, 12.9)	7.5 (5.6, 10.7)	0.000

HAART, Highly active antiretroviral therapy; 3TC, Lamivudine; TDF, Tenofovir disoproxil; EFV, Efavirenz; AZT, Zidovudine; NVP, Nevirapine; WBC, White blood cell; Plt, Platelet; Hb, Hemoglobin; Cr, Creatinine; TG, Triglyceride; TC, Total cholesterol; FPG, Fasting plasma glucose; AST, Aspartate aminotransferase; ALT, Alanine aminotransferase; T.BIL, Total bilirubin. Data are presented as N (%) or Median (IQR). values were determined by χ² test or Wilcoxon signed rank test.