Research Article

An Adaptive Information Borrowing Platform Design for Testing Drug Candidates of COVID-19

Table 1

Operating characteristics of proposed platform design with comprehensive screening strategy.

 Proposed information-borrowing platform designNonborrowing
ScenarioDrugHazard ratioMean TTCRPr (reject)Pr (early stopping for efficacy)Pr (early stopping for futility)Pr (reject)

11150.0760.0350.10718693930.086
21.53.330.9390.7800.00212894340.888
3150.0480.0170.113186134520.084
4150.0320.0160.101186149370.078
5150.0430.0170.086188152360.068

21150.0870.0290.09818693930.092
2150.0370.0110.093188145430.093
31.752.860.9990.9870.0008157240.984
4150.0690.0200.061191126650.070
5150.0310.0080.061191153380.078

31150.0810.0320.11418693930.077
2150.0680.0210.104186142440.088
3150.0500.0200.107185148370.087
41.43.570.8680.6510.006144112320.782
5150.0540.0200.116185137480.064

41150.0790.0310.11118693930.067
21.53.330.9370.7860.00212693330.882
31.53.330.9290.7540.00013293390.901
4150.0370.0130.072191140510.063
5150.0260.0090.076191154370.047

51150.0810.0350.09818693930.082
21.53.330.9420.7780.00412390330.883
30.86.250.0050.0050.585144100440.006
4150.0630.0260.085188148400.073
5150.0460.0240.095186150360.082

61150.0810.0350.09818693930.077
21.53.330.9420.7780.00412390330.893
30.86.250.0050.0050.585144100440.003
4150.0630.0260.085188148400.063
51.53.330.9620.8320.00212293290.889

Note. TTCR, time to clinical remission.