An Adaptive Information Borrowing Platform Design for Testing Drug Candidates of COVID-19

Table 3

Operating characteristics of platform design with optimal screening strategy.

Scenario	Drug	Hazard ratio	Mean TTCR (T/C)	Prob (optimal)	Pr (early stopping for efficacy)	Pr (early stopping for futility)
1	1	1	5/5	0.013	0.032	0.105	186	93	93
	2	1.5	3.33/5	0.939	0.781	0.000	125	92	33
	3	1	5/3.33	0.000	0.000	0.916	93	64	29
	4	1	5/3.33	0.003	0.001	0.913	94	67	27
	5	1	5/3.33	0.045	0.002	0.923	90	64	26
2	1	1	5/5	0.000	0.032	0.105	186	93	93
	2	1.5	3.33/5	0.261	0.781	0.000	125	92	33
	3	2	2.5/3.33	0.735	0.455	0.005	162	115	47
	4	1.5	3.33/2.5	0.004	0.001	0.599	140	105	35
	5	1	5/2.5	0.000	0.000	0.999	62	40	22
3	1	1	5/5	0.000	0.032	0.105	186	93	93
	2	1.5	3.33/5	0.153	0.781	0.000	125	92	33
	3	1.7	2.94/3.33	0.219	0.133	0.022	185	133	52
	4	1	5/2.94	0.000	0.000	0.992	77	53	24
	5	2	2.5/2.94	0.628	0.360	0.005	173	138	35
4	1	1	5/5	0.000	0.032	0.105	186	93	93
	2	2	2.5/5	0.997	0.999	0.000	71	47	24
	3	1.7	2.94/2.5	0.003	0.001	0.379	164	105	59
	4	1.5	3.33/2.5	0.000	0.000	0.715	127	95	32
	5	1	5/2.5	0.000	0.000	1.000	56	34	22
5	1	1	5/5	0.000	0.032	0.105	186	93	93
	2	1.2	4.17/5	0.095	0.175	0.012	183	141	42
	3	1.3	3.85/4.17	0.227	0.219	0.021	178	139	39
	4	1.6	3.12/3.85	0.668	0.456	0.005	159	122	37
	5	1.2	4.17/3.12	0.010	0.001	0.636	136	101	35
6	1	1	5/5	0.000	0.032	0.105	186	93	93
	2	1.4	3.57/5	0.000	0.611	0.000	147	111	36
	3	1.8	2.78/3.57	0.024	0.428	0.006	162	118	44
	4	2.2	2.27/2.78	0.371	0.391	0.004	167	125	42
	5	2.7	1.85/2.27	0.605	0.349	0.007	173	132	41