ERC-BiP Functional Protein Pathway for Assessing Endoplasmic Reticulum Stress Induced by SARS-CoV-2 Replication after Cell Invasion

Table 1

Basic information of healthy controls and COVID-19 patients.

	Healthy controls	COVID-19
N	17	46	—
Age	34.00 (28.00, 45.50)	46.50 (31.25, 66.00)	0.083
PCT, ng/ml	—	0.10 (0.05, 0.26)	—
SAA, ng/ml	—	85.311 (17.88, 231.90)	—
K, mmol/L	—	3.78 (3.50, 4.67)	—
Na, mmol/L	—	139.00 (136.90, 142.00)	—
Ca, mmol/L	—	2.25 (2.13, 2.32)	—
IL-6, pg/ml	2.01 (0.91, 3.02)	34.73 (28.39, 66.01)	0.001
IL-10, pg/ml	0.59 (0.32, 4.75)	8.36 (4.75, 9.27)	0.001
Blood cell detection
WBC, 10^9/L	6.36 (5.41, 6.81)	5.80 (4.66, 8.07)	0.933
NEU, 10^9/L	3.59 (3.15, 4.32)	3.69 (2.66, 5.60)	0.565
NEU%	60.20 (53.70, 62.50)	64.50 (54.90, 74.15)	0.058
LYM, 10^9/L	1.84 (1.65, 2.43)	1.35 (0.99, 1.79)	0.001
LYM%	32.50 (28.00, 38.40)	23.90 (14.25, 33.60)	0.002
MONO, 10^9/L	0.33 (0.25, 0.37)	0.44 (0.33, 0.58)	0.001
MONO%	5.30 (4.30, 5.60)	7.50 (5.60, 10.00)	0.001
BASO, 10^9/L	0.04 (0.02, 0.05)	0.02 (0.01, 0.03)	0.001
BASO%	0.70 (0.40, 0.80)	0.30 (0.20, 0.50)	0.001
EOS, 10^9/L	0.13 (0.06, 0.22)	0.09 (0.01, 0.20)	0.196
EOS%	1.10 (2.10, 3.30)	1.50 (0.20, 3.40)	0.180
Coagulation tests
APTT, second	—	36.00 (30.46, 40.00)	—
PT, second	—	13.30 (12.62, 14.20)	—
INR	—	1.09 (1.02, 1.15)	—
D-dimer, μg/L	—	2.04 (0.74, 1050.00)	—
FIB, g/L	—	3.43 (2.80, 4.57)	—

CRP: C-reactive protein; PCT: procalcitonin; SAA: human serum amyloid A; WBC: white blood cell; NEU: neutrophil; LYM: lymphocyte; MONO: monocyte; BASO: basophil; EOS: eosinophils; APTT: activated partial thromboplastin time; PT: prothrombin time; INR: international normalized ratio; FIB: fibrinogen.