ERC-BiP Functional Protein Pathway for Assessing Endoplasmic Reticulum Stress Induced by SARS-CoV-2 Replication after Cell Invasion

Table 2

Comparative analysis of protein and metabolites between healthy controls and COVID-19 patients.

Metabolites	Patient/health				Severe/mild				Total
	log2(FC)		FDR	VIP	log2(FC)		FDR	VIP
ERC-BiP	0.615	0.035	0.003	0.690	0.995	0.018	0.014	1.577	0.019
Lactic acid	−0.946	<0.001	<0.001	1.768	0.167	0.191	0.066	0.471	<0.001
Pyruvic acid	−0.361	0.002	<0.001	0.952	0.156	0.116	0.053	0.412	0.003
Cholesterol	−0.300	0.166	0.014	0.821	0.018	0.400	0.095	0.252	0.263
Melatonin	0.486	<0.001	<0.001	1.098	0.132	0.680	0.152	0.424	0.001
CRP	1.191	0.096	0.008	0.481	2.336	0.002	0.003	1.611	0.004
AGT	2.002	<0.001	<0.001	0.546	2.620	0.000	<0.001	1.859	<0.001
Cer	1.712	<0.001	<0.001	0.967	−0.004	0.353	0.085	0.255	<0.001
SM	−0.947	<0.001	<0.001	1.367	−1.148	0.004	0.004	1.189	<0.001
Oxaloacetic acid	−0.668	0.021	0.002	0.822	0.701	0.070	0.040	0.926	0.009
Malic acid	−0.314	0.017	0.002	0.856	−0.199	0.258	0.075	0.678	0.033
α-ketoglutaric acid	−0.333	0.008	0.001	0.870	−0.369	0.353	0.085	0.960	0.019
Isocitrate acid	0.742	<0.001	<0.001	1.160	−0.327	0.123	0.055	0.767	<0.001
Succinic acid	−0.346	0.012	0.001	0.877	0.362	0.191	0.066	0.721	0.016