Antimicrobial Susceptibility Profiles of Klebsiella pneumoniae Strains Collected from Clinical Samples in a Hospital in Southern Italy

Table 1

Resistance rates of the clinical isolates of Klebsiella pneumoniae to antimicrobial agents.

Klebsiella pneumoniae		2015	2016	2017	2018	2019	2020
Class	Antibiotic	R %; (n.)	R %; (n.)	R %; (n.)	R %; (n.)	R %; (n.)	R %; (n.)
β-lactam/β-lactamase inhibitor combinations	Amoxicillin/clavulanic acid	65.7 (463)	66.1 (498)	58.7 (494)	66.6 (572)	64.6 (814)	60.3 (610)	0.026	0.206
	Piperacillin/tazobactam	64.1 (465)	63.3 (550)	53.6 (584)	47.2 (707)	56.9 (850)	48.8 (637)	<0.0001	<0.0001
Cephalosporins	Ceftazidime	61.8 (466)	65.7 (551)	60.0 (587)	64.6 (704)	64.7 (853)	54.3 (668)	0.0001	0.0319
	Cefotaxime	67.0 (466)	69.1 (551)	62.9 (587)	66.9 (707)	66.8 (840)	56.0 (680)	<0.0001	0.000452
	Cefepime	56.0 (466)	59.2 (551)	46.5 (585)	39.6 (652)	51.9 (476)	51.6 (556)	<0.0001	0.0048
Carbapenems	Ertapenem	44.3 (411)	51.2 (551)	43.9 (586)	33.1 (706)	45.4 (852)	37.4 (431)	<0.0001	0.0016
	Meropenem	49.0 (465)	48.6 (551)	39.7 (585)	30.2 (706)	40.8 (850)	32.1 (663)	<0.0001	<0.0001
	Imipenem	29.2 (465)	33.3 (540)	33.5 (585)	20.9 (651)	23.0 (478)	28.1 (570)	<0.0001	0.0021
Fluoroquinolones	Ciprofloxacin	63.7 (466)	62.3 (551)	61.2 (587)	64.8 (707)	66.4 (853)	55.5 (676)	0.0005	0.16
Aminoglycosides	Gentamicin	31.5 (466)	31.6 (551)	43.1 (587)	40.5 (707)	36.9 (852)	29.4 (660)	<0.0001	0.796
Tetracyclines	Tigecycline	45.5 (279)	52.1 (363)	37.1 (456)	30.8 (448)	28.5 (228)	NA	<0.0001	<0.0001
Others	Fosfomycin	22.7 (463)	27.9 (498)	22.9 (493)	23.2 (573)	37.0 (662)	40.8 (441)	<0.0001	<0.0001
	Trimethoprim/sulfamethoxazole	62.2 (466)	63.7 (551)	63.2 (587)	65.2 (707)	45.4 (853)	33.5 (681)	<0.0001	<0.0001

value with chi-square, value with Cochran–Armitage trend test.