Evaluating Antibiotic Treatment Guideline Adherence to Ongoing Antibiotic Stewardship in a Tertiary Care Setting: A Retrospective Observational Study
Table 2
Univariate and multivariate logistic regression analyses results determining the predictive variables for guideline adherent treatment.
Variables
No. (%) of adherence
No. (%) of nonadherence
Univariate analysis
Multivariate analysisa
OR (95% CI)
P value
AOR (95% CI)
P value
Unit/department (n=354)
General medical ward
56 (38.6)
89 (61.4)
Ref
0.048
Ref
Surgical ward
11 (27.5)
29 (72.5)
1.65 (0.76–3.58)
0.198
1.19 (0.47–3.01)
0.707
Orthopedics
12 (29.3)
29 (70.7)
1.52 (0.71–3.22)
0.274
1.35 (0.53–3.46)
0.531
Urology
1 (6.7)
5 (83.3)
3.14 (0.35–27.63)
0.301
1.93 (0.19–19.13)
0.574
ICU
24 (58.5)
17 (41.5)
0.44 (0.22–0.90)
0.020
0.65 (0.31–1.37)
0.256
Others
30 (37.0)
51 (63.0)
1.07 (0.61–1.87)
0.814
1.29 (0.69–2.43)
0.429
Patient age group (n=354)
Below 45 years
35 (31.8)
75 (68.2)
Ref
0.042
Ref
45–65 years
42 (34.4)
80 (65.6)
0.89 (0.51–1.54)
0.674
1.09 (0.58–2.02)
0.796
>65 years
57 (46.7)
65 (53.3)
0.53 (0.31–0.91)
0.021
0.86 (0.45–1.64)
0.669
Gender (n=354)
Male
82 (40.6)
120 (59.4)
Ref
0.008
—
—
Female
52 (34.2)
100 (65.8)
1.31 (0.85–2.04)
0.221
—
—
Presence of comorbidities (n=347)b
No
23 (24.7)
70 (75.3)
Ref
0.011
Ref
Yes
108 (42.5)
146 (57.5)
0.44 (0.26–0.75)
0.003
0.52 (0.27–1.00)
0.050
Infectious disease diagnosed (n=354)
UTI
33 (37.9)
54 (62.1)
Ref
0.030
—
—
Pneumonia
78 (43.3)
102 (56.7)
0.80 (0.47–1.35)
0.402
—
—
SSTI
23 (26.4)
64 (73.6)
1.70 (0.89–3.24)
0.106
—
—
Empiric antibiotics
Azithromycin
67 (48.6)
71 (51.4)
0.47 (0.30–0.74)
0.001
0.73 (0.42–1.26)
0.255
Piperacillin/tazobactam
54 (44.6)
67 (55.4)
0.65 (0.41–1.02)
0.059
—
—
Ceftriaxone
23 (25.6)
67 (74.4)
2.11 (1.24–3.60)
0.006
2.09 (1.18–3.71)
0.012∗
Amoxicillin/clavulanic acid
28 (38.4)
45 (61.6)
0.97 (0.57–1.65)
0.921
—
—
Meropenem
15 (40.5)
22 (59.5)
0.88 (0.44–1.76)
0.722
—
—
Cefazolin
10 (40.0)
15 (60.0)
1.10 (0.48–2.53)
0.818
—
—
Levofloxacin
3 (13.0)
20 (87.0)
4.37 (1.27–14.99)
0.019
4.63 (1.30–16.53)
0.018
Significance at . AOR = adjusted odds ratio; — = not significantly associated. aOnly included the variables significant at “level 0.1.” bexcluding unknown cases.
