Evaluation of the Efficacy and Safety of Intravenous Immunoglobulin (IVIG) in Moderate-to-Severe Hospitalized COVID-19 Patients: A Randomized, Open-Label Parallel-Group Study

Table 2

Laboratory parameters.

Lab parameter	IVIG + SoC (Day 1)	IVIG + SoC (Day 9)	value	SoC (Day 1)	SoC (Day 9)	value
Number	33	33		26	26
Hb (12-15.5 g/dL)	12.08 ± 1.83	12.30 ± 1.50	0.5957	12.55 ± 2.04	12.28 ± 1.39	0.681
TLC (4000–11000 cells/mm^3)	10736 ± 4900	10443 ± 4094	0.7929	13666 ± 5330	13798 ± 6087	0.925
Polymorphocytes (60–75%)	87 ± 5	79 ± 8	<0.001	89 ± 10	87 ± 9	0.396
Lymphocytes (2–6%)	11 ± 5	18 ± 8	0.0001	9 ± 9	11 ± 7	0.317
P/L ratio	1.82 ± 0.82	2.31 ± 0.93	0.0266	2.20 ± 0.86	2.23 ± 1.07	0.900
Urea (19–43 mg/dL)	38.09 ± 19.22	36.23 ± 14	0.6558	52.15 ± 26.71	42.50 ± 24.96	0.658
Creatinine (0.66–1.26 mg/dL)	0.71 ± 0.22	0.73 ± 0.24	0.5187	0.74 ± 0.35	0.67 ± 0.33	0.821
Na (137–145 mmol/L)	138.76 ± 3.67	137.71 ± 3.58	0.8330	138.58 ± 3.50	137.08 ± 7.14	0.661
K (3.5–5.1 mmol/L)	4.52 ± 0.51	4.59 ± 0.42	0.7015	4.60 ± 0.41	4.40 ± 0.46	0.325
T. Bilirubin (1.3 mg/dL)	0.84 ± 0.34	0.76 ± 0.25	0.2803	0.81 ± 0.43	0.76 ± 0.29	0.305
ALT (5–50 U/L)	79.76 ± 157.25	61.52 ± 79.15	0.2189	63.35 ± 53.91	111.12 ± 181.33	0.641
AST (15–45 U/L)	57.88 ± 56.84	45.19 ± 35.65	0.3911	51.50 ± 26.70	61.92 ± 53.63	0.705
ALP (38–125 U/L)	129.41 ± 50.47	119.06 ± 45.83	0.5019	102.81 ± 50.57	91.31 ± 41.90	0.611
S. Lactate (0.5–1.5 mmol/L)	2.17 ± 0.55	1.92 ± 0.99	0.2094	2.43 ± 0.81	2.33 ± 0.59	0.613
PCT (low risk: <0.5, high risk: >2 ng/mL)	0.94 ± 1.20	0.14 ± 0.20	0.0003	0.91 ± 0.79	0.74 ± 0.48	0.084
Inflammatory markers (serum)
LDH (125–146 U/L)	643.52 ± 254.56	408.45 ± 140.86	<0.001	728.38 ± 229.43	604.08 ± 200.94	0.042
CRP (0.0–0.5 mg/dL)	96.17 ± 52.19	19.53 ± 18.83	<0.001	118.62 ± 100.92	66.83 ± 59.39	0.028
IL6 (<6 pg/mL)	42.41 ± 31.90	19.52 ± 47.65	0.0251	73.64 ± 94.46	60.68 ± 101.69	0.636
S. Ferritin (30–400 ng/mL)	647.80 ± 352.44	614.66 ± 392.81	0.5501	659.81 ± 320.37	638.16 ± 318.71	0.687
INR (0.9–1.1)	1.07 ± 0.19	1.01 ± 0.10	0.1134	1.09 ± 0.11	1.08 ± 0.26	0.809
D-dimer (<500 ng/mL)	1059.31 ± 667.47	654.87 ± 643.54	0.0146	1353.55 ± 961.24	1152.96 ± 767.55	0.409

Bold values denote significant P-values (≤0.05).