Application of Bioinformatics Tools for the Prediction of Helper MicroRNAs for Improvement of Oncolytic Virus Efficacy

Figure 1

Overview of MAVS signaling pathway as a part of innate immune system defense. After detection of Reovirus by viral RNA sensors, they attach to MAVS protein by CARD domain and activate it. So, MAVS activation leads to secretion of different cytokines which induces the immune system and results in antiviral state. Moreover, it triggers JAK-STAT signaling pathway which intensifies virus elimination by production of different ISGs. MAVS blocking by miR-140 inhibits all these processes.