Application of Bioinformatics Tools for the Prediction of Helper MicroRNAs for Improvement of Oncolytic Virus Efficacy

Table 1

The probable immune system proteins which interfere with reovirus replication.

Inhibitory pathways	Protein content	Effects
JAK-STAT	STAT, IRF9, BCL2, P21, mTOR, AKT, PI3K, Ras, Raf, GRB, VIPERIN, and Tyk [5, 6, 9, 17, 19, 21]	Antiviral effects, development of immune system, hematopoiesis, activation or suppression of genes transcription, and regulation of apoptosis following Reovirus infection
IFNI	RIGI, Mda5, IPS-1, TBK1, IKKe, IRF3, IRF7, TRIF, NAP1, FADD, PKR, RIP, TRAF6, IRAK, TAK1, P50, P65, NF-κB, ISRE, TLR3, ISG15, IFITM, and MAVS [6, 9, 17–19, 22]	The first line of antiviral defense, activator of JAK-STAT pathway, and early mediators of innate immune response
Intrinsic apoptosis pathway	Noxa, bid, ISG54, and ISG56 [5, 9, 17]	Antireoviral effect, a regulator for physiological growth control, regulation of tissue homeostasis, and regulation of tumor formation
RNase L	OAS3 [22]	An immune response to RNA viruses and activator of IFN signaling pathway