ApiAP2 Gene-Network Regulates Gametocytogenesis in Plasmodium Parasites

Figure 2

Dynamic expression pattern of 27 PfApiAP2 genes during gametocytogenesis over a 13-day in vivo culture. The map shows time-course expression from the committed ring stage to stage V. Red represents regions where the ApiAP2 gene is highly expressed (), and blue represents regions of low expression (). The white region shows regions where Log₂ concentration expression is equal to or approximately equal to zero (). A micrograph of the gametocyte developmental stages that correlate with the days and dynamic expression of the genes is shown. Ring stage: R; trophozoite stage: T; gametocytes mature through five morphologically distinct stages I-V. The transcriptomic data were extracted from Biljon et al. [27] for the graphical illustration. The images of the gametocyte developing stages were adopted from the Centers for Disease Control and Prevention [89] and Wadi et al. [90].