Severe Inflammation Caused by Coinfection of PCV2 and Glaesserella parasuis Is Associated with Pyroptosis via Noncanonical Inflammasome Pathway

Figure 1

Survival rate of experimental mice and bacterial loads in the lungs. (a) The BALB/c mice were inoculated with 0.2 mL PBS or PCV2 ( TCID₅₀/mouse) for 7 days, and then, the mice were inoculated with G. parasuis ( CFU/mouse). Mice used as control were treated only with PBS at both time points. (b) Bacterial loads in the lungs. Groups of mice were infected prior with either PCV2 or PBS for 7 days and then challenged with G. parasuis (the mice were euthanized at 12 h), and the number of bacteria in the lungs was recorded using CFUs.

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