Severe Inflammation Caused by Coinfection of PCV2 and Glaesserella parasuis Is Associated with Pyroptosis via Noncanonical Inflammasome Pathway

Figure 2

Microscopic observations of lungs and spleens. After 12 h of infection with G. parasuis, the mice were euthanized. The lungs and spleens were isolated, fixed, stained with HE, and observed by microscopy (scale bar is 50 μm). (a) Lungs showed only slight bleeding and were observed for PCV2 or G. parasuis infection, but there were destroyed alveoli, thickened alveoli septum, and pulmonary congestion in the coinfection group. (b) Follicles of the coinfection group were depleted and disintegrated.