Plasmodium berghei-Mediated NRF2 Activation in Infected Hepatocytes Enhances Parasite Survival

Figure 6

Schematic representation of NRF2 activation in P. berghei infected hepatocytes. (1) Immediately after infection, the PVM of P. berghei parasites is labelled with host cell LC3 which is known to recruit p62 to the PVM [27]. (2) p62 at the PVM is phosphorylated at S349 (S351 of mouse p62) and recruits KEAP1. (3) KEAP1 interaction with p62 leads to the release and therefore to the activation of NRF2. (4) NRF2 activation enhances parasite survival by controlling oxidation levels that are elevated by infection with Plasmodium. Schematic created with BioRender.com.