Modeling Dengue Immune Responses Mediated by Antibodies: Insights on the Biological Parameters to Describe Dengue Infections

Figure 2

Flow chart: Immunological responses mediated by antibodies for a primary dengue infection. Magenta lines represent the transitions of infection related stages, with susceptible target cells, monocytes/dendritic cells, and macrophages, becoming infected cells and presenting cells, respectively. The full red line represents the viral replication, proportional to the death rate of an infected cell. Dashed red lines represent the viral particles removal during the infection process of a susceptible cell. The green lines represent the production rates of the antibodies by the presenting cells, first (left hand side) and then (right hand side) antibody types. Dashed blue and orange lines represent the binding and removal rates for antibodies-virus and virus-antibodies, respectively. The full orange lines represent the transitions of free antibodies particles to antibody-DENV complexes, after the free antibody binds into the free viral particle. Black lines represent the recruitment and decay rates of the model variables.